Effects of Adrenaline Infusion on Platelet Number, Volume and Release Reaction

K Lande; K Gjesdal; E Fønstelien; S E Kjeldsen; I Eide

doi:10.1055/s-0038-1657870

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1985; 54(02): 450-453
DOI: 10.1055/s-0038-1657870

Original Article

Schattauer GmbH Stuttgart

Effects of Adrenaline Infusion on Platelet Number, Volume and Release Reaction

Authors

K Lande

The Department of Medicine and Department of Clinical Physiology, Ullevål Hospital, University of Oslo, Oslo, Norway
K Gjesdal

The Department of Medicine and Department of Clinical Physiology, Ullevål Hospital, University of Oslo, Oslo, Norway
E Fønstelien

The Department of Medicine and Department of Clinical Physiology, Ullevål Hospital, University of Oslo, Oslo, Norway
S E Kjeldsen

The Department of Medicine and Department of Clinical Physiology, Ullevål Hospital, University of Oslo, Oslo, Norway
I Eide

The Department of Medicine and Department of Clinical Physiology, Ullevål Hospital, University of Oslo, Oslo, Norway

Abstract

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Summary

At the end of a diagnostic right heart catheterization ten patients received an intravenous infusion of l-adrenaline which gradually increased the arterial plasma adrenaline concentration from resting physiological values to high values as seen during myocardial infarction, pheochromocytoma and hypoglycemia. Blood was sampled from the brachial artery, femoral vein and hepatic vein. During the adrenaline infusion venous beta-thromboglobulin concentrations increased 23% from 61 ± 5 to 80 ± 7 μg/l (mean ± SE), arterial platelet counts 20% from 212 ± 17 to 253 ± 25 × 10⁹/l and arterial platelet volume 4% from 7.25 ± 0.20 to 7.56 ± 0.21 femtoliter. All changes were significant at the 5% level. Thus, acute increments of arterial plasma adrenaline significantly stimulated the blood platelet parameters studied.

Keywords

Beta-thromboglobulin - Catecholamines - Platelet function - Thrombosis

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Referenzen

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