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Thromb Haemost 1985; 54(02): 387-389
DOI: 10.1055/s-0038-1657745
Original Article
Schattauer GmbH Stuttgart

Comparison Between Subcutaneous and Intravenous DDAVP in Mild and Moderate Hemophilia A

L De Sio
The Department of Human Biopathology, Section of Hematology, University of Rome, “La Sapienza”, Rome, Italy
,
G Mariani
The Department of Human Biopathology, Section of Hematology, University of Rome, “La Sapienza”, Rome, Italy
,
M G Muzzucconi
The Department of Human Biopathology, Section of Hematology, University of Rome, “La Sapienza”, Rome, Italy
,
A Chistolini
The Department of Human Biopathology, Section of Hematology, University of Rome, “La Sapienza”, Rome, Italy
,
M C Tirindelli
The Department of Human Biopathology, Section of Hematology, University of Rome, “La Sapienza”, Rome, Italy
,
F Mandelli
The Department of Human Biopathology, Section of Hematology, University of Rome, “La Sapienza”, Rome, Italy
› Author Affiliations
Further Information

Publication History

Received 07 February 1985

Accepted 12 April 1985

Publication Date:
18 July 2018 (online)

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Summary

Sixteen patients with mild and moderate hemophilia were given Desmopressin (DDAVP) subcutaneously in the absence of any actual bleeding. The response to the drug – in terms of factor VIII coagulant activity rise – became apparent 15 min after the injection, reaching the maximal response after one hour (x̄ 3.2 times the baseline levels; SD 1.21). This response was not different from that elicited using the intravenous route in 18 hemophiliacs of comparable severity after the same time interval. No local or general side-effects were recorded after the subcutaneous administration of DDAVP. We therefore conclude that the subcutaneous route adds further evidence to the reliability of this alternative treatment in mild factor VIII deficiencies, thus making home treatment with this vasopressin analogue possible.

Keywords

DDAVP - Hemophilia A - Mild hemophilia - Subcutaneous DDAVP
 

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