Thromb Haemost 1997; 78(02): 840-844
DOI: 10.1055/s-0038-1657638
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Schattauer GmbH Stuttgart

Physical Activity, Fibrinogen Plasma Level and Gene Polymorphisms in Postmenopausal Women

Rainer Rauramaa
1  The Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, Finland
,
Sari Väisänen
1  The Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, Finland
,
Aulikki Nissinen
2  The Department of Community Health and General Practice, University of Kuopio, Finland
,
Tuomo Rankinen
1  The Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, Finland
,
IIkka Penttilä
3  The Department of Clinical Chemistry, Kuopio University Hospital, Finland
,
Seppo Saarikoski
4  The Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland
,
Jaakko Tuomilehto
5  The National Public Health Institute, Helsinki, Finland
,
Jacques Gagnon
6  The Physical Activity Sciences Laboratory, Laval University, Quebec, Canada
,
Louis Pérusse
6  The Physical Activity Sciences Laboratory, Laval University, Quebec, Canada
,
Claude Bouchard
6  The Physical Activity Sciences Laboratory, Laval University, Quebec, Canada
› Author Affiliations
Further Information

Publication History

Received 28 1996

Accepted after resubmission 25 March 1997

Publication Date:
12 July 2018 (online)

Summary

The relations between habitual physical activity (PA), fibrinogen gene polymorphisms and plasma fibrinogen were investigated in 191 postmenopausal women. Subjects who reported PA at least 4 times/ week had lower fibrinogen level (3.19 g/1; 95% Cl 3.10; 3.27) than women reporting PA 2-3 times/week (3.43 g/1; 3.29; 3.58) or sedentary subjects (3.64 g/1; 3.33; 3.94). There were no differences in plasma fibrinogen across the α-fibrinogen (Rsal, TaqI) or (β-fibrinogen (Mnll, Bell, Hindlll) genotypes, the frequencies of which were in a Hardy- Weinberg equilibrium. An interaction between Rsal, which was in complete linkage disequilibrium with TaqI, and PA on plasma fibrinogen was observed, even after adjustments for BMI, smoking and medication (p = 0.024). Among women homozygous for the common Rsal allele, the physically most active had lower fibrinogen level (p <0.001) compared to the physically less active subjects. These results suggest that, in postmenopausal women, the relation between physical activity and plasma fibrinogen is modulated by genetic variation in the α-fibrinogen gene.