Thrombopoietin (Mpl-ligand) and the Regulation of Platelet Production

Karine Cohen-Solal; Najet Debili; William Vainchenker; Françoise Wendling

doi:10.1055/s-0038-1657497

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1997; 78(01): 037-041
DOI: 10.1055/s-0038-1657497

Thrombopoietin

Schattauer GmbH Stuttgart

Thrombopoietin (Mpl-ligand) and the Regulation of Platelet Production

Authors

Karine Cohen-Solal

Inserm U326, Institut Gustave Roussy, Villejuif, France
Najet Debili

Inserm U326, Institut Gustave Roussy, Villejuif, France
William Vainchenker

Inserm U326, Institut Gustave Roussy, Villejuif, France
Françoise Wendling

Inserm U326, Institut Gustave Roussy, Villejuif, France

Abstract

PDF Download

PDF (1052 kb)

References

References
1 Souyri M, Vigon I, Penciolelli J-F, Heard JM, Tambourin P, Wendling F. A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors. Cell 1990; 63: 1137-1147
2 Methia N, Louache F, Vainchenker W, Wendling F. Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis. Blood 1993; 82: 1395-1401
3 Gurney AL, Carver-Moore K, de Sauvage FJ, Moore MW. Thrombocytopenia in c-mpl-deficient mice. Science 1994; 265: 1445-1447
4 Bartley TD, Bogenberger J, Hunt P. et al. Identification and cloning of a megakaryocyte growth and development factor that its a ligand for the cytokine receptor Mpl. Cell 1994; 77: 1117-1124
5 de Sauvage FJ, Hass PE, Spencer SD. et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-MPL ligand. Nature 1994; 369: 533-538
6 Lok S, Kaushansky K, Holly RD. et al. Cloning and expression of murine thrombopoietin and stimulation of platelet production in vivo. Nature 1994; 369: 565-568
7 Kato T, Ogami K, Shimada Y. et al. Purification and characterization of thrombopoietin. J Biochem 1995; 118: 229-236
8 Kuter DJ, Beeler DL, Rosenberg RD. The purification of megapoietin: A physiological regulator of megakaryocyte growth and platelet production. Proc.Natl.Acad.Sci USA 1994; 91: 11104-11108
9 Wendling F, Maraskovsky E, Debili N. et al. c-Mpl ligand is a humoral regulator of megakaryocytopoiesis. Nature 1994; 369: 571-574
10 Harker LA, Marzec UM, Hunt P. et al. Dose-response effects of pegylated human megakaryocyte growth and development factor on platelet production and function in nonhuman primates. Blood 1996; 88: 511-521
11 Banu N, Wang JF, Deng B, Groopman JE, Avraham H. Modulation of megakaryocytopoiesis by thrombopoietin: The c-Mpl ligand. Blood 1995; 86: 1331-1338
12 Choi ES, Nichol JL, Hokom MM, Homkohl AC, Hunt P. Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional. Blood 1995; 85: 402-413
13 Zeigler FC, de Sauvage F, Widmer HR. et al. In vitro megakaiyocytopoietic and thrombopoietic activity of c-mpl ligand (TPO) on purified murine hematopoietic stem cells. Blood 1994; 84: 4045-4052
14 Debili N, Wendling F, Katz A. et al. The Mpl-Ligand or thrombopoietin or megakaryocyte growth and development factor has both direct proliferative and differentiative activities on human megakaryocyte progenitors. Blood 1995; 86: 2516-2525
15 Choi ES, Hokom MM, Bartley TD. et al. Recombinant human megakaryocyte growth and development factor (MGDF), a ligand for c-mpl, produces functional platelets in vitro. Stem Cell 1995; 95: 2973-2978
16 Kobayashi M, Laver JH, Kato T, Miyazaki H, Ogawa M. Thrombopoietin supports proliferation of human primitive hematopoietic cells in synergy with steel factof and/or interleukin-3. Blood 1996; 88: 429-436
17 Ku H, Yonemura Y, Kaushansky K, Ogawa M. Thrombopoietin, the ligand/or the Mpl receptor, synergizes with Steel Factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 1996; 87: 4544-4551
18 Sitnicka E, Lin N, Priestley GV. et al. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 1996; 87: 4998-5005
19 de Sauvage FJ, Carver-Moore K, Luoh SM. et al. Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin. J. Exp.Med 1996; 183: 651-656
20 Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D. Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietin receptor c-mpl. Blood 1996; 87: 2162-2170
21 Carver-Moore K, Broxmeyer HE, Luoh SM. et al. Low levels of erythroid and myeloid progenitors in thrombopoietin-and c-mpl-deficient mice. Blood 1996; 88: 803-808
22 Kaushansky K, Lok S, Holly RD. et al. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand, thrombopoietin. Nature 1994; 369: 568-571
23 Ulich TR, del Castillo J, Yin S. et al. Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice. Blood 1995; 86: 971-976
24 Farese AM, Hunt P, Boone T, MacVittie TJ. Recombinant human megakaryocyte growth and development factor stimulates thrombocytopoiesis in normal nonhuman primates. Blood 1995; 86: 54-59
25 Hokom MM, Lancey D, Kinstler OB. et al. Pegylated megakaryocyte growth and development factor abrogates the lethal thrombopenia associated with carboplatin and irradiation in mice. Blood 1995; 86: 4486-4492
26 Farese AM, Hunt P, Grab LB, MacVittie TJ. Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia. J. Clin.Invest. 1996; 97: 2145-2151
27 Fibbe WE, Heemskerk DPM, Laterveer L. et al. Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice. Blood 1995; 86: 3308-3313
28 Kaushansky K, Broudy VC, Grossmann A. et al. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy. J. Clin.Invest. 1995; 96: 1683-1687
29 Grossmann A, Lenox J, Deisher TA. et al. Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice. Blood 1996; 88: 3363-3370
30 Molineux G, Hartley CA, McElroy P, McCrea C, McNiece IK. Megakaryocyte growth and development factor stimulates enhanced platelet recovery in mice after bone marrow transplantation. Blood 1996; 88: 1509-1514
31 Molineux G, Hartley C, McElroy P, McCrea C, McNiece IK. Megakaryocyte growth and development factor accelerates platelet recovery in peripheral blood progenitor cell transplant recipients. Blood 1996; 88: 366-376
32 O’Malley CJ, Rasko RL, Basser RL. et al. Administration of pegylated recombinant human megakaryocyte growth and development factor to human stimulates the production of functional platelets that show no evidence of in vitro activation. Blood 1996; 88: 3288-3298
33 Archimbaud E, Ottmann O, Lui Yin JA. et al. A randomised, double-blind, placebo-controlled study using PEG-rhuMGDF as an adjunct to chemotherapy for adults with de-novo acute myeloid leukaemia (AML): Early results. Blood 1996; 88 (Suppl. 01) 447
34 Vadhan-Raj S, Patel S, Broxmeyer HE. et al. Phase I-II investigation of recombinant human thrombopoietin (rhTPO) in patients with sarcoma receiving high dose chemotherapy (CT) with adriamycin (A) and ifosfamide (I). Blood 1996; 88 (Suppl. 01) 448
35 Miyakawa Y, Oda A, Druker BJ. et al. Thrombopoietin induces tyrosine phosphorylation of stat3 and stat5 in human blood platelets. Blood 1996; 87: 439-446
36 Toombs CF, Young CH, Glaspy JA, Vamum BC. Recombinant human megakaryocyte growth and development factor (MGDF) moderately enhances ex vivo platelet aggregation by a receptor dependent mechanism. Thrombosis Research 1995; 80: 23-33
37 Chen J, Herced-Harjacek L, Groopman JE, Grabarek J. Regulation of platelets activation in vitro by the c-Mpl ligand, thrombopoietin. Blood 1995; 86: 4054-4062
38 Harker LA, Hunt P, Marzec UM. et al. Regulation of platelet production and function by megakaryocyte growth and development factor in nonhuman primates. Blood 1996; 87: 1833-1844
39 Sungaran R, Markovic B, Chong BH. Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow and spleen using in situ hybridization. Blood 1996; 89: 101-107
40 de Gabriele G, Pennington DG. Regulation of platelet production. Brit. J. Haematol 1967; 13: 210-216
41 Kuter DJ, Rosenberg RD. Appearance of a megakaryocyte growth-promoting activity, megapoietin, during acute thrombocytopenia in the rabbit. Blood 1994; 84: 1464-1472
42 Cohen-Solal K, Villeval JL, Titeux M, Lok S, Vainchenker W, Wendling F. Constitutive expression of Mpl ligand transcript during thrombocytopenia and thrombocytosis. Blood 1996; 88: 2578-2584
43 Fielder PJ, Gurney AL, Stefanich E. et al. Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets. Blood 1996; 87: 2154-2161
44 Stoffer R, Wiestner A, Skoda RC. Thrombopoietin in thrombocytopenic mice: Evidence against regulation at the mRNA level and for a direct regulatory role of platelets. Blood 1996; 87: 567-573
45 Shivdasani RA, Rosenblatt MF, Zucker-Franklin D. et al. Transcription factor NF-E2 is required for platelet formation independent of actions of thrombopoietin/MGDF in megakaryocyte development. Cell 1995; 81: 695-704
46 Mukai HY, Kojima H, Todokoro K. et al. Serum thrombopoietin (TPO) levels in patients with amegakaryocytic thrombocytopenia are much higher than those with immune thrombocytopenic purpura. Thrombosis and Haemostasis 1996; 76: 675-678
47 Ichikawa N, Ishida F, Shimodaira S, Tahara T, Kato T, Kitano K. Regulation of serum thrombopoietin levels by platelets and megakaryocytes in patients with aplastic anaemia and idiopathic thrombocytopenia purpura. Thrombosis and Haemostasis. 1996; 76: 156-160
48 Nagahisa H, Nagata Y, Ohnuki T. et al. Bone marrow stromal cells produce thrombopoietin an stimulate megakaryocyte growth and maturation but suppress proplatelet formation. Blood 1996; 87: 1309-1316