Failure of Salicylate to Reduce Inhibition of Human Venous Prostacyclin in Synthesis by Conventional Dose Aspirin

Summary

Ex vivo venous prostacyclin synthesis was measured in 24 patients who received no medication, or a single oral dose of aspirin 300 mg, sodium salicylate, 500 mg, or a combination of sodium salicylate 500 mg followed by aspirin 300 mg 1 1/2 or 3 hr later. Aspirin alone substantially reduced PGI₂ synthesis but sodium salicylate alone had no effect. Sodium salicylate administration prior to aspirin did not reverse the inhibitory effect of aspirin on PGI₂ synthesis.

Keywords

Aspirin - Salicylate - Prostacyclin

• References

• 1 Fields WS. Controlled trial of aspirin in cerebral ischaemia. Stroke 1977; 08: 301-315
• 2 Steering Committee MRC. Effect of aspirin on post-operative venous thrombosis. Lancet 1972; 02: 441-445
• 3 Elwood PC, Sweetnam PM. Aspirin and secondary mortality after myocardial infarction. Lancet 1979; 02: 1313-1315
• 4 Aspirin Myocardial Infarction Study Group. A randomised controlled trial of aspirin in persons recovered from myocardial infarction. JAMA 1980; 243: 661-669
• 5 Burch JW, Baenziger NL, Stanford N, Majerus PW. Sensitivity of fatty acid cyclooxygenase from human aorta to acetylation by aspirin. Proc Nat Acad Sci 1978; 75: 5181-5184
• 6 Baenziger NL, Becherer PR, Majerus PW. Characterisation of prostacyclin synthesis in cultured human arterial smooth muscle cell, venous endothelial cells and skin fibroblasts. Cell 1979; 16: 967-974
• 7 Hanley SP, Bevan J, Cockbill SR, Heptinstall S. Differential inhibition by low dose aspirin of human venous prostacyclin synthesis and platelet thromboxane synthesis. Lancet 1981; 01: 969-971
• 8 Merino J, Livio M, Rajtar G, Gaetano GDe. Salicylate reverses in vitro aspirin inhibition of rat platelets and vascular prostaglandin generation. Biochem Pharmacol 1980; 29: 1093-1096
• 9 Cerletti C, Livio M, Castellarnau CDe, Dejana E, Gaetano GDe. Salicylate interferes in vivo with aspirin induced inhibition of platelet and vascular prostaglandin generation in rats. Prostaglandins Leukotrienes Med 1982; 08: 263-264
• 10 Poyser NL. Development and use of a radioimmunoassay for measuring 6 oxo prostaglandin F_1α . Dev Pharmacol 1980; 01: 44-55
• 11 Preston FE, Whipps S, Jackson CA, French AJ, Wyld PJ, Stoddard CJ. Inhibition of prostacyclin synthesis and platelet thromboxane A₂after low dose aspirin. N Eng J Med 1981; 304: 76-79