In Vitro Thrombogenicity Tests of Factor IX Concentrates

C V Prowse; A Chirnside; R A Elton

doi:10.1055/s-0038-1657035

Thrombosis and Haemostasis, Inhaltsverzeichnis

Thromb Haemost 1979; 42(05): 1355-1367
DOI: 10.1055/s-0038-1657035

Original Article

Schattauer GmbH Stuttgart

In Vitro Thrombogenicity Tests of Factor IX Concentrates

I. A Survey of Available Assays

C V Prowse

The South-East Scotland Regional Blood Transfusion Centre, Royal Infirmary, Edinburgh

,

A Chirnside

The South-East Scotland Regional Blood Transfusion Centre, Royal Infirmary, Edinburgh

,

R A Elton

^*Medical Computing and Statistics Unit, Medical School, Edinburgh

The South-East Scotland Regional Blood Transfusion Centre, Royal Infirmary, Edinburgh

› Institutsangaben

Abstract

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Summary

Various factor IX concentrates have been examined in a number of in vitro tests of thrombogenicity. The results suggest that some tests are superfluous as in concentrates with activity in any of these tests activation is revealed by a combination of the non-activated partial thromboplastin time, the thrombin (or Xa) generation time and factor VIII inhibitor bypassing activity tests. Assay of individual coagulant enzymes revealed that most concentrates contained more factor IXa than Xa. However only a small number of concentrates, chiefly those that had been purposefully activated, contained appreciable amounts of either enzyme.

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Referenzen

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