The Relation of Factors XII, XI, and IX to Hypercoagulable States^{[*] [**]}

Summary

Evidence has been obtained in rabbits that the reduction of the silicone whole blood clotting time to the normal glass range reflects a hypercoagulable state attributable to circulating activated factors XII and XI. The potential clinical implications of these findings are discussed.

^* This study was supported by research grants H-1027 and HTS-5235 from the National Institutes of Health and by a grant-in-aid from the American Heart Association.

^** Presented in part before American Physiological Society, Atlantic City, New Jersey, April 15, 1962.

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