Thromb Haemost 1969; 21(02): 362-366
DOI: 10.1055/s-0038-1653546
Originalarbeiten - Original Articles - Travaux Originaux
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Inhibition of Platelet Adhesiveness and Aggregation by Benzyl Alcohol and Phenol

A.J Zweifler
1  Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
,
S.S Sanbar
1  Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan
› Author Affiliations
Further Information

Publication History

Publication Date:
10 June 2018 (online)

Summary

Two amphipathic alcohols, benzyl alcohol and phenol, have been found to diminish adhesiveness of platelets to glass beads and to impair adenosine diphosphate (ADP)-induced platelet aggregation, while ethanol and isopropanol, both completely water soluble, had no inhibitory effects. Comparatively, phenol is a more potent inhibitor than benzyl alcohol. It is suggested that the basis for their antiadhesive effect may be similar to that which underlies their local anesthetic properties.