Thrombosis and Haemostasis, Table of Contents Thromb Haemost 1981; 46(04): 757-758DOI: 10.1055/s-0038-1653470 Original Article Schattauer GmbH Stuttgart Delayed Elimination of Fibrin from the Lungs in Rats Given α2-Antiplasmin G Carlin The Institute of Forensic Medicine, University of Uppsala, Sweden and Kabi/Vitrum AB, Stockholm, Sweden , M Einarsson The Institute of Forensic Medicine, University of Uppsala, Sweden and Kabi/Vitrum AB, Stockholm, Sweden , T Saldeen The Institute of Forensic Medicine, University of Uppsala, Sweden and Kabi/Vitrum AB, Stockholm, Sweden › Author AffiliationsRecommend Article Abstract PDF Download Buy Article Summary Injection of human α2–antiplasmin resulted in delayed elimination of fibrin from the lungs in rats with thrombin–induced intravascular coagulation. The amount of α2–antiplasmin injected was chosen so as to simulate the posttraumatic increase of this inhibitor in man. By injecting trace amounts only of radiolabelled α2–antiplasmin a specific uptake of this protein in the lungs was noted after the thrombin-induced coagulation. The results may indicate that the posttraumatic increase in α2–antiplasmin is of significance for the delayed elimination of fibrin seen in patients following trauma. Keywords Keywordsα2–antiplasmin - Adult respiratory distress syndrome - Fibrinolysis in vivo PDF (156 kb) References References 1 Busch C, Dahlgren S, Jakobsson S, Jung B, Modig J, Saldeen T. The use of125I-labelled fibrinogen for determination of fibrin trapping in the lungs in patients developing the microembolism syndrome. Acta Anaesthesiol Scand 1975; Suppl 57: 46-54 2 Saldeen T. The microembolism syndrome. Microvasc Res 1976; 11: 227-259 3 Saldeen T. The microembolism syndrome. In: The Microembolism Syndrome. Publ: Almqvist & Wiksell Int; Stockholm: 1979: 7-44 4 Collen D. On the regulation and control of fibrinolysis. Thromb Haemostas 1980; 43: 77-89 5 Bagge L, Saldeen T. The primary fibrinolysis inhibitor and trauma. Thromb Res 1978; 13: 1131-1136 6 Bagge L, Rammer L, Saldeen T. Experimental study of the importance of plasminogen activation inhibition for decreased elimination of intravascular fibrin after trauma. Forensic Sd 1973; 2: 54-55 7 Wiman B, Collen D. Purification and characterisation of human antiplasmin, the fast-acting plasmin inhibitor in plasma. Eur J Biochem 1977; 78: 19-26 8 Busch C, Rammer L, Saldeen T. Quantitation of fibrin deposition and elimination in organs of rats injected with labelled fibrinogen and albumin. Thrombos Diathes haemorrh 1973; 29: 94-107 9 Nilsson IM, Olow B. Determination of fibrinogen and fibrinogenolytic activity. Thrombos Diathes haemorrh 1962; 8: 297-310 10 Carlin G, Modig J, Saldeen T. Effect of infusion of dextran 70 on fibrinolysis inhibition activity in human serum. Acta Chir Scand 1979; 145: 129-131 11 Hogstorp H, Jacobsson H, Saldeen T. Effect of hepatectomy on the posttraumatic fibrinolysis inhibition and the primary fibrinolysis inhibitor in the rat. Thromb Res 1980; 18: 361-368 12 Koie K, Kamiya T, Ogata K, Takamatsu J. α2-plasmin-inhibitor defidency (Miyasato disease). Lancet 23.12.1978; 1334-1336
