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Thromb Haemost 1968; 19(03/04): 526-532
DOI: 10.1055/s-0038-1651231
DOI: 10.1055/s-0038-1651231
Originalarbeiten – Original Articles – Travaux Originaux
Antifibrinolytic Action of the Anticoagulant Split Product of Fibrinogen
Authors
Further Information
Publication History
Publication Date:
27 June 2018 (online)
Summary
The purified anticoagulant split product of fibrinogen has antifibrinolytic and anti-fibrinogenolytic activity. This was investigated by lysis times of fibrin and by the rate of disappearance of fibrinogen in plasma and in a purified system. A new method was used to measure fibrinogenolytic activity. In the experimental system which we have used no indication of additional breakdown of the anticoagulant split product in the presence of fibrinolysin was obtained.
* Supported by Grant NIH 1P01 HE 10893-01 of the U. S. Public Health Service.
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References
- 1 Nanninga L.B, Guest M.M. Preparation and properties of anticoagulant split product of fibrinogen and its determination in plasma.. Thrombos. Diathes. haemorrh. (Stuttg.) 1967; 17: 440
- 2 Ware A.G, Guest M.M, Seegers W.H. Fibrinogen : with special reference to its preparation and certain properties of the product.. Arch. Biochem 1947; 13: 231
- 3 Maxwell R.W, Nickel V.S, Lewandowski V. Preparation of plasminogen deficient fibrinogen and thrombin.. Biochem. biophys. Res. Coram 1962; 7: 50
- 4 Ambrus C.M, Markus G. Plasmin-antiplasmin complex as a reservoir of fibrinolytic enzyme.. Amer. J. Physiol 1960; 199: 491
- 5 Nanninga L.B, Guest M.M. Repid determination of antifibrinolysin (antiplasmin) in plasma.. Thrombos. Diathes. haemorrh. (Stuttg.) 1966; 15: 273
- 6 Nanninga L.B. Rapid determination of Profibrinolysin (plasminogen) in plasma.. Thrombos. Diathes. haemorrh. (Stuttg.) 1967; 17: 8
- 7 Berg W, Korsen- Bengtsen K, Ygge J. Plasminogen assay by means of the lysis time method.. Thrombos. Diathes. haemorrh. (Stuttg.) 1965; 14: 127
- 8 Bobbins K.C, Summaria L, Elwyn D, Barlow J.H. Further studies on the purification and characterization of human plasminogen and plasmin.. J. biol. Chem 1965; 240: 541
- 9 Bobbins K.C, Summaria L, Hsieh B, Shah R.J. The peptide chains of human plasmin.. J. biol. Chem 1967; 242: 2333
- 10 Latallo Z.S, Budzynski A.Z, Lipinski B, Kowalski E. Inhibition of thrombin and of fibrin polymerization, two activities derived from plasmin digested fibrinogen.. Nature (Lond.) 1964; 203: 1184
- 11 Triantaphyllopoulos D.C. Enzymatic effects of fibrinolysin.. Fed. Proc 1965; 24: 800
- 12 Nanninga L.B, Guest M.M. On the interaction of fibrinolysin (plasmin) with the inhibitors antifibrinolysin and soybean trypsin inhibitor.. Arch. Biochem 1964; 108: 542
- 13 Triantaphyllopoulos E, Triantaphyllopoulos D.C. Variable and invariable components of the anticoagulant fraction of incubated fibrinogen.. Nature (Lond.) 1966; 209: 265
- 14 Fletcher A.P, Alkjaersig N, Sherry S. Pathogenesis of the coagulation defect developing during pathological plasma proteolytic (fibrinolytic) states, I. The significance of fibrinogen proteolysis and circulatory fibrinogen breakdown products.. J. clin. Invest 1962; 41: 896
- 15 Bang N.U. Normal and abnormal fibrin polymerization.. Thrombos. Diathes. haemorrh. (Stuttg.) 1963; 13: 131
- 16 Niléhn J.E. Split products of fibrinogen after prolonged interaction with plasmin.. Thrombos. Diathes. haemorrh. (Stuttg.) 1967; 18: 89
- 17 Belier F.K, Maki M. Properties of fibrinogenolysis and fibrinolysis products in immune assays.. Thrombos. Diathes. haemorrh. (Stuttg.) 1967; 18: 114