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Thromb Haemost 1968; 19(03/04): 526-532
DOI: 10.1055/s-0038-1651231
Originalarbeiten – Original Articles – Travaux Originaux
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Antifibrinolytic Action of the Anticoagulant Split Product of Fibrinogen

L. B Nanninga
1   Department of Physiology, University of Texas Medical Branch, Galveston, Texas
,
M. M Guest   *
1   Department of Physiology, University of Texas Medical Branch, Galveston, Texas
› Author Affiliations
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Publication Date:
27 June 2018 (online)

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Summary

The purified anticoagulant split product of fibrinogen has antifibrinolytic and anti-fibrinogenolytic activity. This was investigated by lysis times of fibrin and by the rate of disappearance of fibrinogen in plasma and in a purified system. A new method was used to measure fibrinogenolytic activity. In the experimental system which we have used no indication of additional breakdown of the anticoagulant split product in the presence of fibrinolysin was obtained.

* Supported by Grant NIH 1P01 HE 10893-01 of the U. S. Public Health Service.


 

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