The Efficacy of Neutral Position Beractant Administration in Neonates

Karen Kovey; Kelsi Barnes; Robert D. Beckett; Melissa Rice

doi:10.1055/s-0038-1649483

American Journal of Perinatology, Table of Contents

Am J Perinatol 2018; 35(13): 1303-1307
DOI: 10.1055/s-0038-1649483

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Efficacy of Neutral Position Beractant Administration in Neonates

Karen Kovey

¹Department of Pharmacy, Mission Health System, Asheville, North Carolina

,

Kelsi Barnes

²Department of Pharmacy, Children's Hospital of Wisconsin, Milwaukee, Wisconsin

,

Robert D. Beckett

³College of Pharmacy, Natural and Health Sciences, Manchester University, Fort Wayne, Indiana

,

Melissa Rice

⁴Neonatal Intensive Care Medicine, Parkview Women's and Children's Hospital, Fort Wayne, Indiana

› Author Affiliations

Abstract

Objective The objective was to compare the efficacy and adverse effects of beractant administration in neonates via a single aliquot in a neutral position versus positioning the neonates on their left then right side and two aliquots administration.

Study Design This was a retrospective cohort chart review of neonates who were diagnosed with respiratory distress syndrome and received beractant during two 15-month periods between 2013 and 2015 and 2015 and 2016 to compare the change in the fraction of inspired oxygen (FiO₂) 1 hour after beractant administration.

Results There were no differences in FiO₂ 1 hour after beractant between groups (p = 0.617). Adverse events and other comorbidities did not differ between the groups.

Conclusion Changing administration of beractant from two aliquots and positions to a neutral position resulted in no significant change in FiO₂ and may be considered as an option for administration in neonates.

Keywords

neonate - beractant - surfactant - administration - outcome - safety

Full Text

References

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