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Thromb Haemost 1972; 27(03): 452-460
DOI: 10.1055/s-0038-1649385
Originalarbeiten — Original Articles — Travaux Originaux
Schattauer GmbH

Thrombocytopenia Caused by Antigen-Antibody Reactions with Special Reference to Intravascular Coagulation

G Fedder
1   Department for Blood Coagulation Research, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
,
Elisabeth M. Prakke
1   Department for Blood Coagulation Research, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
,
J Vreeken
1   Department for Blood Coagulation Research, Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
› Institutsangaben
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Publikationsdatum:
29. Juni 2018 (online)

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Summary

Soluble antigen-antibody complexes were infused in a group of non-immunized rabbits. Furthermore, antigen solutions were infused or injected into a group of rabbits, immunized with the corresponding antigen. In both groups a profound fall in the number of blood platelets was demonstrated. However, increased or decreased factor V activity was not seen in any of the rabbits; changes in the level of fibrinogen did not occur, and circulating fibrin monomers as a sign of thrombinemia could not be found.

The mechanism by which immunologieally induced thrombocytopenia can lead to diffuse intravascular coagulation is briefly discussed.

 

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