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Thromb Haemost 1972; 27(03): 452-460
DOI: 10.1055/s-0038-1649385
DOI: 10.1055/s-0038-1649385
Originalarbeiten — Original Articles — Travaux Originaux
Thrombocytopenia Caused by Antigen-Antibody Reactions with Special Reference to Intravascular Coagulation
Further Information
Publication History
Publication Date:
29 June 2018 (online)
Summary
Soluble antigen-antibody complexes were infused in a group of non-immunized rabbits. Furthermore, antigen solutions were infused or injected into a group of rabbits, immunized with the corresponding antigen. In both groups a profound fall in the number of blood platelets was demonstrated. However, increased or decreased factor V activity was not seen in any of the rabbits; changes in the level of fibrinogen did not occur, and circulating fibrin monomers as a sign of thrombinemia could not be found.
The mechanism by which immunologieally induced thrombocytopenia can lead to diffuse intravascular coagulation is briefly discussed.
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References
- 1 Bloch K. J. The anaphylactic antibody of the rabbit. In: Progress and Allergy. Ed. S. Karger, Basel; New York: 1967
- 2 Blombäck M, Johansson S. A, Sjöberg H. E. Coagulation factors and defibrination syndrome in anaphylaxis. Acta physiol, scand 04: 313 1967;
- 3 Casillas G, Simonetti G, Pavlovsky A. Chromatographic behaviour of clotting factors. Brit. J. Haemat 16: 363 1969;
- 4 Epstein E, Quick A. J. Effect of injecting platelet extract intravenously. Proc. Soc. exp. Biol. (N.Y) 83 4: 53 1953;
- 5 Evensen S. A, Jeremic M, Hjort P. P. Die Rolle der Thrombocyten für die Auslösung intravascularer Gerinnung. Bibi, haemat. (Basel) 32: 292 1969;
- 6 Evensen S. A, Jeremic M. Platelets and the triggering mechanism of intravascular coagulation. Brit. J. Haemat 19: 33 1970;
- 7 Fedder G, Prakke ElisabethM, Vreeken J. On the early detection of intravascular coagulation. An experimental study. Thrombos. Diathes. haemorrh. (Stuttg.) 27 : 365 1972;
- 8 Feissly R, Lüdin H. Microscopie par contrastes de phase (III. Applications à l’hématologie). Rev. Hémat 04: 481 1949;
- 9 Grant R. T, Rothschild P. A device for estimating blood-pressure in the rabbit. J. Physiol 81: 265 1934;
- 10 Horowitz H. I, Des Prez R. M, Hook E. W. Effects of bacterial endotoxin on rabbit platelets II. Enhancement of platelet factor 3 activity in vitro and in vivo. J. exp. Med 116: 619 1962;
- 11 Johansson S. A. Inhibition of thrombocytopenia and 5-hydroxytryptamine release in anaphylactic shock by heparin. Acta physiol, scand 50: 95 1960;
- 12 Johansson S. A. Studies on platelets and heparin during sensitization and anaphylaxis. Acta allerg 19: 142 1964;
- 13 Kabat E. A, Mayer M. M. Experimental immunochemistry. 22 C.C. Thomas; Springfiels: (Ill.) 1961
- 14 Kojoeloff M, Kopeloff L. M. Blood platelets in anaphylaxis. J. Immunol 40: 471 1941;
- 15 Lasch H. G. Coagulation disturbances in shock. Postgrad. Med 45: 539 1969;
- 16 Lecomte J, Bounameaux Y. Thrombocytes et réactions anaphylactiques générales du lapin. Path, et Biol 06: 1535 1958;
- 17 Lindqvist K. J. A unique class of rabbit immunoglobulins eliciting passive cutaneous anaphylaxis in homologous skin. Immuno chemistry 05: 525 1968;
- 18 Loghem van J. J, von dem Borne A. E. G, van der Hart Mia, Peetoom F. Immune adherence and blood cell destruction. Vox Sang 12: 361 1967;
- 19 Miescher P, Cooper N. The fixation of soluble antigenantibody complexes upon thrombocytes. Vox Sang 05: 138 1960;
- 20 Müller-Berghaus G, Goldfinger O, Margaretten W, McKay D. G. Platelet factor 3 and the generalized Shwartzman reaction. Thrombos. Diathes. haemorrh. (Stuttg) 18: 726 1967;
- 21 Müller-Berghaus G, Mueller-Eckhardt Ch. Induction of consumption coagulopathy (disseminated intravascular coagulation) with special reference to Hageman factor activation by unrelated immune reactions. XIII Int. Congr. Haematol. Munich 1970
- 22 Rodriguez-Erdmann F. Intravascular activation of the clotting system with phospholipids. Production of the generalized Shwartzman reaction with platelet factor 3. Blood 26: 541 1965;
- 23 Salmon J, Lambert P. H, Hiernaux M. Coagulation intravasculaire et phénomènes anaphylactiques. Nouv. Rev. franç. Hémat 08: 76 1968;
- 24 Schneider C. L, Claxton E. B, Hughes C. H, Johnson S. A. Bovine platelets in large quantities properties and activities concerned with hemostasis. Amer. J. Physiol 179: 236 1954;
- 25 Stormorken H. The preparation of proaccelerin deficient (parahemophilia) plasma for the assay of proaccelerin. Scand. J. clin. Lab. Invest 09: 273 1957;
- 26 Strengers Th, Asberg E. G. M. Een screeningtest, gevolgd door een snelle kwantitatieve microbepaling van fibrinogeen in plasma. Ned. T. Geneesk 107: 2044 1963;
- 27 Waalkes T. P, Weissbach H, Bozivevich J, Udenfriend S. Serotonin and histamine release during anaphylaxis in the rabbit. J. clin. Invest 36: 1115 1957;
- 28 Yoshida T, Yoshida H, Kasukawa R. Thrombelastographic studies on coagulation under influence of antigen-antibody reactions. Int. Arch. Allergy 38: 627 1970;