Use of ¹²⁵I-Fibrinogen Kinetic Data to Detect Disseminated Intravascular Coagulation and Deposition of Fibrin in Patients with Metastatic Cancer

Summary

A technique using computerized data handling for following the fate of ¹²⁵I-fibrinogen through various physiological compartments is presented. Its use in detecting fibrin build up in patients with metastatic tumors and cancer-caused DIC is explained. An increase in j_3u (fractional catabolic rate as seen in the urine data) throughout the course of a study was found to be an important indicator of extravascular fibrin build up.

• References

• 1 Anscombe F. J. Rejection of outliers. Technometrics 1960; 2: 123
• 2 Atencio A. T, Bailey H. R, Reeve E. B. Studies on the metabolism and distribution of fibrinogen in younger and older rabbits. Journal of Laboratory and Clinical Medicine 1965; 66: 1
• 3 Atencio A. T, Reeve E. B. Studies on the metabolism and distribution of fibrinogen in younger and older rabbits. II. Results. Journal of Laboratory and Clinical Medicine 1965; 66: 20
• 4 Baker L. R. I, Rubenberg M. L, Dacie J. V, Brain M. D. Fibrinogen catabolism in microangiographic haemolytic anaemia. British Journal of Haematology 1968; 14: 617
• 5 Bard Y. Nonlinear Parameter Estimation. Academic Press; N. Y.: 1974
• 6 Berson S. A, Yalow R. S, Schreiber S. S, Post J. Tracer experiments with ¹³¹ I labelled human serum albumin: Distribution and degradation studies. Journal of Clinical Investigation 1953; 32: 746
• 7 Bettigole R. E. Labelled Fibrinogen: A Brief Review. Journal of Medicine 1973; 4: 55
• 8 Bettigole R. E, Himelstein E. S, Shiu M. H, Martini N, Clifford G. O, Fortner J. G. ¹³¹I fibrinogen survival after liver and lung transplantation: A possible index of graft rejection. In: Kurt N. von Kaulla, (Ed.) Coagulation Problems in Transplanted Organs. Charles C. Thomas, Publisher; Springfield, 111.: 1972: 24
• 9 Brodsky I. (Ed.) Anticoagulation in the Treatment of Cancer. Journal of Medicine 1974; a 5: 1
• 10 Brodsky I. Preface. Journal of Medicine 1974; b 5: 5
• 11 Brodsky I. Leukemia and the hypercoagulable state. Pathogenic and therapeutic implications. Journal of Medicine 1974; 5: 38
• 12 Brodsky I, Ross E. M, Petkow G, Kahn S. B. Platelet and fibrinogen kinetics with (⁷³Se) — Selenomethionine in patients with myeloproliferative disorders. British Journal of Haematology 1972; 22: 179
• 13 Campbell R. M, Cuthbertson D. P, Matthews C. M, Macfarlane A. S. Behavior of ¹⁴C and ¹³¹I labelled plasma proteins in the rat. International Journal of Applied Radiation and Isotopes 1956; 1: 66
• 14 Chemical Rubber Company. Handbook of Probability and Statistics. Cleveland; Ohio.: 1966
• 15 Donato L, Vitek F, Bianchi R, Federighi G. A double tracer method for metabolic studies with iodinated proteins or polypeptides in presence of a relatively slow excretion of iodide. Journal of Nuclear Biological Medicine 1967; 11: 21
• 16 Draper N, Smith H. Applied Regression Analysis. Wiley; New York.: 1966
• 17 Laki K. Fibrinogen and Metastases. Journal of Medicine 1974; 5: 32
• 18 Macfarlane A. S. In vivo behavior of ¹³¹I fibrinogen. Journal of Clinical Investigation 1963; 42: 346
• 19 Marder V. J, Shulman N. R, Carroll W. R. High Molecular weight derivatives of human fibrinogen produced by plasmin: I. Physiochemical and immunological characterization. Journal of Biological Chemistry 1969; 244: 2111
• 20 Martinez J, Shapiro S. S, Holburn R. R. Metabolism of human prothrombin and fibrinogen in patients with thrombocytosis secondary to myeloproliferative states. Blood 1973; 42: 35
• 21 Martinez J, Holburn R. R, Shapiro S. S, Erslev A. J. Fibrinogen Philadelphia: A hereditary hypodysfibrinogenemia characterized by fibrinogen hypercatabolism. Journal of Clinical Investigation 1974; 53: 600
• 22 Matthews C. M. E. The theory of tracer experiments with ¹³¹I labelled plasma proteins. Physics in Medicine and Biology 1957; 2: 36
• 23 Prakash R. A Mathematical Model of Human Circulation. System, Masters Thesis Department of Medicine; S.U.N.Y. at Buffalo.: 1974
• 24 Reeve E. B, Bailey H. R. Mathematical models describing the distribution of ¹³¹I albumin in man. Journal of Laboratory and Clinical Medicine 1962; 60: 923
• 25 Reeve E. B, Franks J. J. Fibrinogen Synthesis,Distribution and Degradation. Seminars in Thrombosis and Hemostasis 1974; 1: 129
• 26 Regoeczi E. Fibrinogen Catabolism. Kinetics of catabolism following sudden elevation of the pool with exogenous fibrinogen. Clinical Science 1970; a 38: 111
• 27 Regoeczi E. Abnormal fibrinogen metabolism. In: Rothschild, M. A. (ed.) Plasma Protein Metabolism, Academic Press; New York: 459 1970. b
• 28 Recoeczi E. Iodine-labelled fibrinogen: A Review. British Journal of Haematology 1971; 20: 649
• 29 Riggs D. S. The Mathematical Approach to Physiological Problems. M.I.T. Press; Cambridge, Mass.: 1963
• 30 Rosenbrock H. H, Storey C. Computational Techniques for Chemical Engineers. Pergamon Press; N.Y.: 1966
• 31 Sherman L. A. Fibrinogen turnover: Demonstration of multiple pathways of catabolism. Journal of Laboratory and Clinical Medicine 1972; 79: 710
• 32 Straub P. W. Chronic intravascular coagulation: Clinical spectrum and diagnostic criteria with special emphasis on metabolism,distribution and localization of ¹³¹I fibrinogen. Acta Medical Scandinavia Supp 1971; 526: 1
• 33 Takeda Y. Studies of the metabolism and distribution of fibrinogen in patients with rheumatoid arthritis. Journal of Laboratory and Clinical Medicine 1967; 69: 624
• 34 Takeda Y, Reeve E. B. Studies of the metabolism and distribution of albumin with autologous ¹³¹I albumin in healthy men. Journal of Laboratory and Clinical Medicine 1963; 61: 183
• 35 Woods S. Experimental studies on the spread of cancer, with special reference to fibrinolytic agents and anticoagulants. Journal of Medicine 1974; 5: 7