Summary
The effect of lidoflazine and of cinnarizine on human platelet function in vitro was compared to that of dipyridamole.
Pre-incubation for 30 min at 37° C of platelet rich plasma with lidoflazine or with
dipyridamole 5 ×10–4 M resulted in an appreciable inhibition of collagen aggregation in particular and
to a lesser extent of ADP aggregation; cinnarizine was marginally active only.
Clot retraction was inhibited by lidoflazine and by dipyridamole. Experiments on biphasic
ADP aggregation and C14-serotonin release during aggregation show that lidoflazine reduces the platelet release
reaction.
The possible mode of action of the compound is discussed.
Plasma coagulation and PF – 3 availability were not affected.
