Enhancement by ADP of Thrombin-induced Aggregation in ADP-refractory Platelets

Nicole Simard-Duquesne

doi:10.1055/s-0038-1647784

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 1973; 29(02): 445-449
DOI: 10.1055/s-0038-1647784

Original Article

Schattauer GmbH

Enhancement by ADP of Thrombin-induced Aggregation in ADP-refractory Platelets

Authors

Nicole Simard-Duquesne

¹Ayerst Research Laboratories, Montreal, Quebec, Canada

Abstract

Summary

In ADP-refractory rat platelets, thrombin-induced aggregation is enhanced in the presence of ADP and inhibited in the absence of ADP. Two mechanisms are proposed for thrombin-induced platelet aggregation: one through ADP release which may become refractory, and a second mechanism in which thrombin acts synergistieally with ADP.

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References

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