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Thromb Haemost 1973; 29(01): 190-195
DOI: 10.1055/s-0038-1647759
DOI: 10.1055/s-0038-1647759
Original Article
Effects “in Vitro” of Some Cardiovascular Drugs and Other Agents on Human Platelet Aggregation
Weitere Informationen
Publikationsverlauf
Received
24. Juli 1972
Publikationsdatum:
24. Juli 2018 (online)
Summary
The in vitro effect of the following substances on human platelet aggregation is studied: K 4423 (a ß-blocking drug), isoproterenol, phentolamine, papaverine, methamidoline (a myolytic agent).
None of these substances causes aggregation. All inhibit aggregation induced by ADP or noradrenaline, except for phentolamine, which is active only on noradrenaline- induced aggregation.
Hypothesis on the mechanism of action of the compounds tested are proposed.
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