Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00035024.xml
Download PDF
Thromb Haemost 1973; 29(01): 190-195
DOI: 10.1055/s-0038-1647759
DOI: 10.1055/s-0038-1647759
Original Article
Effects “in Vitro” of Some Cardiovascular Drugs and Other Agents on Human Platelet Aggregation
Further Information
Publication History
Received
24 July 1972
Publication Date:
24 July 2018 (online)
Summary
The in vitro effect of the following substances on human platelet aggregation is studied: K 4423 (a ß-blocking drug), isoproterenol, phentolamine, papaverine, methamidoline (a myolytic agent).
None of these substances causes aggregation. All inhibit aggregation induced by ADP or noradrenaline, except for phentolamine, which is active only on noradrenaline- induced aggregation.
Hypothesis on the mechanism of action of the compounds tested are proposed.
-
References
- 1 Ahtee L, Michal F. 1972. Effect of sympathomimetic amines on rabbit platelet aggregation in vitro. Proceedings of the British Pharmacological Society. London: 4-6 January 1972, 63.
- 2 Amer M. S. 1969; Mechanism of action of eholecystokinin. Clinical Research 17: 520.
- 3 Born G. V. R, Cross M. J. 1963; The aggregation of blood platelets. Journal of Physiology 168: 178.
- 4 Born G. V. R, Mills D. C. B, Roberts G. C. K. 1967; Potentiation of platelet aggregation by adrenaline. The Journal of Physiology 191: 43.
- 5 Bucher H. W, Stucki P. 1969; The effect of various beta-receptor blocking agents on platelet aggregation. Experimentia 25: 280.
- 6 Giraldi P. N, Nannini G, Logbmann W, Franceschini J, Passerini N. 1969; Sintesi di 1 - oxo -N - alchil - 3 - amino -f enil -isoindoline. In: “Convegno di Ohimica del Farmaco e dei Prodotti Biologicamente attivi” Rome, (Italy) 15-18 december, 1969. Abstracts 75 1..
- 7 Haslam R. J, Taylor A. 1971; Effects of cathecolamines on the formation of adenosine 3’ : 55-cyclic monophosphate in human blood platelets. Biochemical Journal 125: 377.
- 8 Ktjkovetz W. R, Poch G. 1970; Inhibition of cyclic-35, 55-nucleotide-phosphodiesterase as a possible mode of action of papaverine and similarly acting drugs. Naunyn-Schmiedebergs Archiv für Pharmakologie und Experimentelle Pathologie 267: 189.
- 9 Lauria F, Vecchietti Y, Rabini T, Tommasini R, Buonamici M, Usardi M. M. Derivatives of 1,4-methano and 1,4-ethano-1,2,3,4-tetrahydronaphthalene as ß-adrenergic blocking agents. (In preparation.)
- 10 Markwardt F, Hoffmann A. 1970; Effects of papaverine derivatives on cyclic AMP phosphodiesterase of human platelets. Biochemical Pharmacology 19: 2519.
- 11 Mills D. C. B, Roberts G CK. 1967; Effect of adrenaline on human blood platelets. Journal of Physiology 193: 443.
- 12 Moskowitz J, Harwood J. P, Reid W. D. Krishna 1961; The interaction of norepinephrine and prostaglandin Ex on the adenyl cyclase system of human and rabbit blood platelets. Biochimica et Biophisica Acta 230: 279.
- 13 Robison G. A, Butcher R. W, Sutherland E. W. 1970. On the relation of hormone receptors to adenyl cyclase. In: Danielli J. F, Moran J. F, Triggle D. J. (eds.) Fundamental Concepts in Drug-receptor interactions. Academic Press; London: 59.
- 14 Rufeger U, Tellhelm B, Frimmer M. 1971; Inhibition by papaverine of 35,55-nucleotide- phosphodiesterase. (E. C. 3.1.4.1.) from bovine uterus muscle. Naunyn- Schmiedebergs Archiv, für Pharmakologie und Experimentelle Pathologie 270: 428.
- 15 Rysanek K, Svehla C, Spânkova H, Mlejnkovâ M. 1968; Comparison of the effect of various sympathicolytics on thrombocyte aggregation. Journal of Pharmacy and Pharmacology 20: 154.
- 16 Smith J. B, Mills D CB. 1970; Inhibition of adenosine 3’ : ö’-cyclic monophosplmte phosphodiesterase. The Biochemical Journal 120: 20.