Am J Perinatol 2018; 35(S 01): S1-S26
DOI: 10.1055/s-0038-1647087
Abstracts
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Urinary Netrin-1 Concentration in Healthy Full-Term Newborns

M. Kamianowska
1   Department of Neonatology and Neonatal Intensive Care, Medical University of Bialystok, Bialystok, Poland
,
M. Szczepański
1   Department of Neonatology and Neonatal Intensive Care, Medical University of Bialystok, Bialystok, Poland
,
E. E. Kulikowska
1   Department of Neonatology and Neonatal Intensive Care, Medical University of Bialystok, Bialystok, Poland
,
B. Bebko
1   Department of Neonatology and Neonatal Intensive Care, Medical University of Bialystok, Bialystok, Poland
,
A. Koput
2   Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Bialystok, Poland
,
A. Wasilewska
3   Department of Pediatrics and Nephrology, Medical University of Bialystok, Bialystok, Poland
› Author Affiliations
Further Information

Publication History

Publication Date:
27 April 2018 (online)

 

Introduction: Monitoring of renal function in acute kidney injury in pediatric population is complicated by the lack of age-related reference values of new biomarkers. Urinary netrin-1 is a new marker that is associated with early kidney damage. The aim of this study was to determine the normal levels of urinary netrin-1 in healthy full-term newborns.

Materials and Methods: This study included 88 healthy full-term neonates born from normal, uncomplicated pregnancies. The concentration of netrin-1 was determined in urines obtained in the first or second day of life with a commercially available ELISA kit.

Results: Male and female newborns, as well as children in whom the samples were obtained in the first or second day of life, did not differ significantly in terms of their urinary netrin-1 levels. We found a negative correlation between both the urinary netrin-1 level and urinary netrin-1 level after normalization for urinary creatinine and the birth weight.

Conclusion: This is the first report of urinary netrin-1 levels in healthy full-term newborns during the first postnatal days. We hope that the results are useful in further clinical studies. Our study has some limitations, in that it is a single-center study and has a relatively small sample size. A larger study with more subjects needs to be conducted to assess the variation in urinary netrin-1 levels in full-term and preterm neonates.

Keywords: healthy, netrin-1, newborn, normal ranges