Am J Perinatol 2018; 35(12): 1142-1147
DOI: 10.1055/s-0038-1646948
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Application of Stem Cells to Infertility Treatment with Emphasis on Mesenchymal Stem Cells and Ovarian Stem Cells

Nahid Lorzadeh
1   Department of Obstetrics and Gynecology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran
Nastaran Kazemirad
2   Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
› Author Affiliations
Funding All the fees were provided by research center fund and deployed accordingly.
Further Information

Publication History

04 January 2018

20 February 2018

Publication Date:
01 May 2018 (online)


Stem cells are a population of undifferentiated cells that originated from embryonic and fetal stages of development. Stem cells possess the potency to produce cells that ultimately form different tissues and organs. They are considered as potential alternative novel therapeutic agents for patients suffering from infertility due to their unlimited source and high differentiation potency. There are several studies that have shown that different types of stem cells (mesenchymal stem cells, embryonic, endometrial, and ovarian stem cells) can be differentiated into both spermatozoa and oocytes in vitro, proving their potential clinical use in management and cure of infertility issues. Furthermore, mouse model studies have shown that ovarian stem cells, when cultured in vitro, can differentiate into a mature oocyte; however, there are still a lot of debates and complications attached to this concept. In addition, this is yet to be established using human ovarian stem cells, but, if established, would be a novel fertility preservation and treatment technique for women with infertility-related complications. This review gives comprehensive details of the available clinical application of stem cells in infertility treatment.