Abstract
Stem cells are a population of undifferentiated cells that originated from embryonic
and fetal stages of development. Stem cells possess the potency to produce cells that
ultimately form different tissues and organs. They are considered as potential alternative
novel therapeutic agents for patients suffering from infertility due to their unlimited
source and high differentiation potency. There are several studies that have shown
that different types of stem cells (mesenchymal stem cells, embryonic, endometrial,
and ovarian stem cells) can be differentiated into both spermatozoa and oocytes in
vitro, proving their potential clinical use in management and cure of infertility
issues. Furthermore, mouse model studies have shown that ovarian stem cells, when
cultured in vitro, can differentiate into a mature oocyte; however, there are still
a lot of debates and complications attached to this concept. In addition, this is
yet to be established using human ovarian stem cells, but, if established, would be
a novel fertility preservation and treatment technique for women with infertility-related
complications. This review gives comprehensive details of the available clinical application
of stem cells in infertility treatment.
Keywords
infertility - spermatozoa - mesenchymal stem cells - ovarian stem cells - undifferentiated
cells