Effect of 4-Hydroxy-2,3-trans-nonenal on Platelet Function

Summary

4-Hydroxy-2,3-trans-nonenal (HNE), an aldehyde end-product of lipid peroxidation, potentiated aggregation and increased thromboxane A₂ formation in platelets challenged with ADP, thrombin or the ionophore A23187. These effects were observed at HNE concentrations in the range 10-100 μM. Platelet responses to collagen, epinephrine and arachidonic acid were not affected by PINE. Concentrations of HNE in excess of 100 pM inhibited platelet activation. HNE increased the release of ³H-arachidonic acid from prelabelled platelet phospholipids in response to thrombin or ADR It is proposed that HNE may play an important role in controlling platelet function by regulating the activity of phospholipase A₂.

Keywords

Platelet - 4-Hydroxy-2,3-trans-nonenal-lipid peroxidation

• References

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