Thromb Haemost 1988; 59(02): 143-146
DOI: 10.1055/s-0038-1642743
Original Articles
Schattauer GmbH Stuttgart

Effect of 4-Hydroxy-2,3-trans-nonenal on Platelet Function

Michael L Selley
The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
,
Julie A McGuiness
The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
,
Lynn A Jenkin
The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
,
Mark R Bartlett
The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
,
Neville G Ardlie
The Cardiovascular Research Group, Department of Medicine and Clinical Science, John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia
› Author Affiliations
Further Information

Publication History

Received 16 June 1987

Accepted after revision 29 October 1987

Publication Date:
21 May 2018 (online)

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Summary

4-Hydroxy-2,3-trans-nonenal (HNE), an aldehyde end-product of lipid peroxidation, potentiated aggregation and increased thromboxane A2 formation in platelets challenged with ADP, thrombin or the ionophore A23187. These effects were observed at HNE concentrations in the range 10-100 μM. Platelet responses to collagen, epinephrine and arachidonic acid were not affected by PINE. Concentrations of HNE in excess of 100 pM inhibited platelet activation. HNE increased the release of 3H-arachidonic acid from prelabelled platelet phospholipids in response to thrombin or ADR It is proposed that HNE may play an important role in controlling platelet function by regulating the activity of phospholipase A2.