The Impact of Hypoxemia on the Development of Retinopathy of Prematurity in Infants Less Than 29 Weeks of Gestation

Narges Afshar; Ronald J. Baier; Mohamed Tagin; Cecilia de Cabo; John Minski; Yasser N. Elsayed

doi:10.1055/s-0038-1641588

American Journal of Perinatology, Table of Contents

Am J Perinatol 2018; 35(12): 1148-1153
DOI: 10.1055/s-0038-1641588

Original Article

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

The Impact of Hypoxemia on the Development of Retinopathy of Prematurity in Infants Less Than 29 Weeks of Gestation

Authors

Narges Afshar

¹Section of Neonatology, Department of Paediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Ronald J. Baier

¹Section of Neonatology, Department of Paediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Mohamed Tagin

¹Section of Neonatology, Department of Paediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Cecilia de Cabo

¹Section of Neonatology, Department of Paediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
John Minski

¹Section of Neonatology, Department of Paediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada
Yasser N. Elsayed

¹Section of Neonatology, Department of Paediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada

Abstract

Objective To study the impact of cumulative exposure to hypoxemia on the development of retinopathy of prematurity (ROP) in preterm infants less than 29 weeks' gestation.

Study Design This is a retrospective analysis of the effect of cumulative exposure to hypoxemia during the first 10 weeks of life in preterm infants <29 weeks' gestation. Cumulative time spent at various levels of oxygen saturation was calculated by converting the daily percentage of time to minutes per day. Cumulative exposure to hypoxemia (cT_<80 or oxygen saturation <80%) was calculated weekly and compared between outcomes. The primary outcome was the development of ROP requiring treatment.

Results Cumulative hypoxemia exposure was significantly associated with ROP requiring treatment. When adjusted for other neonatal morbidities, only gestation was consistently associated with ROP requiring treatment.

Conclusion Cumulative exposure to hypoxemia in the first few weeks was not associated with ROP or treatment of ROP after adjustment for confounders.

Keywords

hypoxemia - retinopathy of prematurity - oxygen histogram

Full Text

References

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