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DOI: 10.1055/s-0038-1637043
ENDOSCOPIC ALLPICATION OF NEW HEMOSTATIC POWDER (UI-EWD®) IN GASTROINTESTINAL BLEEDING
Publication History
Publication Date:
27 March 2018 (online)
Aims:
This was a prospective study investigating the efficacy of UI-EWD® in patients with various gastrointestinal bleeding. The UI-EWD powder was applied to post-ESD/EMR ulcer or to the bleeding sites undergoing insufficient hemostasis.
Methods:
We evaluate
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the success rate of hemostasis
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re-bleeding rate on second-look endoscopy at the next day,
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Persistent rate of UI-EWD® on ulcer base at follow-up endoscopy, and
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clogging rate of spraying catheter during applying UI-EWD®.
Results:
A total of 57 patients were enrolled. The bleeding developed in 46 patients with post-endoscopic resection ulcers (41 ESD induced ulcers and 5 EMR induced ulcers), 8 patients with peptic ulcers and 3 patients with miscellaneous bleeding.
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Success rates of hemostasis in acute bleeding were 94.8% (55/58) of UI-EWD® group.
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Re-bleeding rates were 6.9% (4/58) of UI-EWD® group.
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Persistent rate of UI-EWD® on ulcer base was 70.2% (26/37) 1 day after the procedure, and 38.4% (15/38) 3 days after the procedure.
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Clogging rate of spraying catheter was 4.4% (2/45).
Conclusions:
The endoscopic application of UI-EWD® is effective for the acute GI bleeding. The hemostatic action of UI-EWD appears to be from high mucoadhesiveness and hydrogel persistence. In addition, a newly developed delivery system shows less scattering and more targeted properties onto ulcer base.