Endoscopy 2018; 50(04): S7
DOI: 10.1055/s-0038-1637043
ESGE Days 2018 oral presentations
20.04.2018 – GI bleeding
Georg Thieme Verlag KG Stuttgart · New York

ENDOSCOPIC ALLPICATION OF NEW HEMOSTATIC POWDER (UI-EWD®) IN GASTROINTESTINAL BLEEDING

YW Shin
1   Inha University School of Medicine, Division of Gastroenterology, Department of Internal Medicine, Incheon, Korea, Republic of
,
BW Bang
2   INHA University Hospital, Gastroenterology, Incheon, Korea, Republic of
,
K Kwon
1   Inha University School of Medicine, Division of Gastroenterology, Department of Internal Medicine, Incheon, Korea, Republic of
,
HK Kim
1   Inha University School of Medicine, Division of Gastroenterology, Department of Internal Medicine, Incheon, Korea, Republic of
,
DH Lee
1   Inha University School of Medicine, Division of Gastroenterology, Department of Internal Medicine, Incheon, Korea, Republic of
› Author Affiliations
Further Information

Publication History

Publication Date:
27 March 2018 (online)

 

Aims:

This was a prospective study investigating the efficacy of UI-EWD® in patients with various gastrointestinal bleeding. The UI-EWD powder was applied to post-ESD/EMR ulcer or to the bleeding sites undergoing insufficient hemostasis.

Methods:

We evaluate

  1. the success rate of hemostasis

  2. re-bleeding rate on second-look endoscopy at the next day,

  3. Persistent rate of UI-EWD® on ulcer base at follow-up endoscopy, and

  4. clogging rate of spraying catheter during applying UI-EWD®.

Results:

A total of 57 patients were enrolled. The bleeding developed in 46 patients with post-endoscopic resection ulcers (41 ESD induced ulcers and 5 EMR induced ulcers), 8 patients with peptic ulcers and 3 patients with miscellaneous bleeding.

  1. Success rates of hemostasis in acute bleeding were 94.8% (55/58) of UI-EWD® group.

  2. Re-bleeding rates were 6.9% (4/58) of UI-EWD® group.

  3. Persistent rate of UI-EWD® on ulcer base was 70.2% (26/37) 1 day after the procedure, and 38.4% (15/38) 3 days after the procedure.

  4. Clogging rate of spraying catheter was 4.4% (2/45).

Conclusions:

The endoscopic application of UI-EWD® is effective for the acute GI bleeding. The hemostatic action of UI-EWD appears to be from high mucoadhesiveness and hydrogel persistence. In addition, a newly developed delivery system shows less scattering and more targeted properties onto ulcer base.