Maternal Age at Delivery and Enzyme Polymorphisms in Children with Type 1 Diabetes Mellitus

Fulvia Gloria-Bottini; Anna Neri; Patrizia Saccucci; Maria Luisa Manca Bitti; Novella Rapini; Gabriele Renzetti; Andrea Magrini; Egidio Bottini

doi:10.1055/s-0038-1636930

Journal of Child Science, Table of Contents

CC-BY-NC-ND 4.0 · Journal of Child Science 2018; 08(01): e7-e10
DOI: 10.1055/s-0038-1636930

Original Article

Georg Thieme Verlag KG Stuttgart · New York

Maternal Age at Delivery and Enzyme Polymorphisms in Children with Type 1 Diabetes Mellitus

Fulvia Gloria-Bottini

¹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

,

Anna Neri

¹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

,

Patrizia Saccucci

¹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

,

Maria Luisa Manca Bitti

²Department of Medical Science, Pediatric Diabetes Unit, University of Rome Tor Vergata, Rome, Italy

,

Novella Rapini

²Department of Medical Science, Pediatric Diabetes Unit, University of Rome Tor Vergata, Rome, Italy

,

Gabriele Renzetti

¹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

,

Andrea Magrini

¹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

,

Egidio Bottini

¹Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy

› Author Affiliations

Abstract

Fetal genetic adaptation to environment of aging women could result in positive selection of genes that during extrauterine life increases the risk of type 1 diabetes mellitus (T1DM). We have examined the distribution of three genetic polymorphisms (acid phosphatase locus 1 [ACP₁], p53 codon 72, and PTPN22) involved in T1DM risk in relation to maternal age at delivery. p53 codon 72 was determined in 281 T1DM children, ACP₁ in 207 children, and PTPN22 in 216 children. Controls (blood donors) were 351 for ACP₁, 271 for PTPN22, and 730 for p53 codon 72. Genotypes were determined by DNA analysis. The proportions of the three genotypes associated with T1DM are much greater in T1DM children from older mothers than in those from young mothers and in controls. The data support the hypothesis that advanced maternal age favors a positive selection of genes more adapted to the uterine environment of older women: these genes predispose to T1DM during extrauterine life.

Keywords

ACP₁ - maternal age - p53 codon 72 - PTPN22 - type 1 diabetes mellitus

Full Text

References

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