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Methods Inf Med 1997; 36(04/05): 257-260
DOI: 10.1055/s-0038-1636872
Original Article
Schattauer GmbH

Nonlinear Pattern Analysis of Ventricular Premature Beats by Mutual Information

M. Osaka
1   Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA
2   First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
,
H. Saitoh
2   First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
,
T. Yokoshima
2   First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
,
H. Kishida
2   First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
,
H. Hayakawa
2   First Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
,
R. J. Cohen
1   Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA, USA
› Author Affiliations
Further Information

Publication History

Publication Date:
19 February 2018 (online)

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Abstract:

The frequency of ventricular premature beats (VPBs) has been related to the risk of mortality. However, little is known about the temporal pattern of occurrence of VPBs and its relationship to autonomic activity. Hence, we applied a general correlation measure, mutual information, to quantify how VPBs are generated over time. We also used mutual information to determine the correlation between VPB production and heart rate in order to evaluate effects of autonomic activity on VPB production. We examined twenty subjects with more than 3000 VPBs/day and simulated ran-( dom time series of VPB occurrence. We found that mutual information values could be used to characterize quantitatively the temporal patterns of VPB generation. Our data suggest that VPB production is not random and VPBs generated with a higher value of mutual information may be more greatly affected by autonomic activity.

Keywords:

Ventricular Premature Beat - Heart Rate - Autonomic Activity - Nonlinear Analysis - Mutual InformationIntroduction
 

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