A problem of identifying the phase response curve of the myocardial pacemaker was
investigated using a simple dynamic system model of cardiac arrhythmia. A hybrid optimization
method of a genetic algorithm and a local optimization technique was employed to obtain
a solution of the model fitting. The method was applied to two categories of arrhythmias,
ventricular parasystole and high-degree AV block. The present study offered a new
insight into the mechanism of cardiac arrhythmias.
Keywords:
Arrhythmia - Phase Response Curve - Ventricular Parasystole - High-degree AV Block