Methods Inf Med 1994; 33(01): 133-138
DOI: 10.1055/s-0038-1634989
Original Article
Schattauer GmbH

The Value to the Anaesthetist of Monitoring Cerebral Activity

R. M. Langford
1   Anaesthetic Laboratory, St. Bartholomew’s Hospital, London, UK
,
C. E. Thomsen
2   Institute of Electronic Systems University of Aalborg, Denmark
› Author Affiliations
Further Information

Publication History

Publication Date:
08 February 2018 (online)

Abstract:

The administration rate of general anaesthetic drugs is at present guided by clinical experience, and indirect indicators such as haemodynamic parameters. In the presence of muscle relaxants most of the clinical signs of inadequate anaesthesia are lost and accidental awareness may occur. A number of monitoring modalities, primarily based on analysis of the electroencephalogram (EEG), have been proposed for measurement of the anaesthetic depth. Moreover intraoperative cerebral monitoring may also provide the anaesthetist with early warning of cerebral ischaemia, or information on specific neurological pathways. To facilitate this, it is essential to combine analysis of the spontaneous EEG with recording of evoked potentials, to assess both cortical and subcortical activity/events. None of the reviewed methods, however promising, can alone meet all of the requirements for intraoperative monitoring of cerebral function. We suggest that the future direction should be to integrate several modalities in a single device, to provide valuable new information, upon which to base clinical management decisions.

 
  • REFERENCES

  • 1 Andersen KS. Det tavse skrig. Daily Danish newspaper Politiken. 1992/12/2.
  • 2 Skovmand K. Det vagne mareridt. Daily Danish newspaper Politiken. 1992/12/3.
  • 3 Skovmand K. Angst nar narkosen svigter. Daily Danish newspaper Politiken. 1992/12/4.
  • 4 Evans JM. Patients’ experience of awareness during general anaesthesia. In: Rosen M, Lunn JN. eds. Consciousness Awareness and Pain in General Anaesthesia. London: Butterworth; 1987: 184-92.
  • 5 Evans JM, Davies WL, Wise CC. Lower oesophageal contractility: a new monitor of anaesthesia. Lancet 1984; I: 1151-4.
  • 6 Mather C, Raftery S, Prys-Roberts C. Somatic movement and oesophageal motility during isoflurane anaesthesia. Br J Anaesth 1992; 69: 40-44.
  • 7 Prior PF, Maynard DE. Monitoring Cerebral Function. Long-term Monitoring of EEG and Evoked Potentials. Amsterdam: Elsevier; 1986
  • 8 Peterson DO, Drummond JC, Todd MM. Effects of halothane, enflurane, isoflurane and nitrous oxide on somatosensory evoked potentials in humans. Anesthesiol 1986; 65: 35-40.
  • 9 Lloyd-Thomas AR, Cole PV, Prior PF. Quantitative EEG and brainstem auditory evoked potentials: Comparison of isoflurane with halothane using the cerebral function analyzing monitor. Br J Anaesth 1990; 65: 306-12.
  • 10 Bickford RG. Automatic electroencephalo-graphic control of general anaesthesia. Electroencephalography Clin Neurophysiol 1950; 02: 93-6.
  • 11 Schwilden H, Schuttler J, Stoeckel H. Closed-loop feedback control of metho-hexital anaesthesia by quantitative EEG analysis in humans. Anesthesiol 1987; 67: 341-7.
  • 12 Rampil IJ, Matteo RS. Changes in EEG spectral edge frequency correlate with haemodynamic response in laryngoscopy and intubation. Anesthesiol 1987; 67: 139-42.
  • 13 Schwilden H, Schuttler J, Stoeckel H. Quantitation of the EEG and pharmacodynamic modelling of hypnotic drugs: etomi-date as an example. Eur J Anaesthesiol 1985; 02: 121-31.
  • 14 Maynard D. Development of the CFM: The Cerebral Function Analyzing Monitor (CFAM). Annales Anesthesiologie Franchise 1979; 20: 253-5.
  • 15 Frank M, Prior PF. The cerebral function analyzing monitor: principles and potential use. In: Rosen M, Lunn JN. eds. Consciousness Awareness and Pain in General Anaesthesia. London: Butterworths; 1987: 61-71.
  • 16 Frank M, Savege TM, Leigh J, Greenwood J, Holly JMP. Comparison of the cerebral function monitor and plasma concentrations of thiopentone and alphaxalone during total i.v. anaesthesia with repeated bolus doses of thiopentone and althesin. Br J Anaesth 1982; 54: 609-16.
  • 17 Plourde G, Picton TW. Long latency auditory evoked potentials during general anaesthesia: Nl and P3 components. Anaesth Analg 1991; 71: 343-50.
  • 18 Dubois MY, Sato S, Chassy J, Macnamara TE. Effect of enflurance on brainstem auditory evoked responses in humans. Anesth Analg 1982; 61: 898-902.
  • 19 Thornton C, Heneghan CPH, James MFM, Jones JG. Effects of halothane or enflurane with controlled ventilation on auditory evoked potentials in man. Br J Anaesth 1984; 56: 315-23.
  • 20 Thornton C, Heneghan CPH, Navaratnara-jah M, Bateman PE, Jones JG. Effect of etomidate on the auditory evoked response in man. Br J Anaesth 1985; 57: 554-61.
  • 21 Sebel PS, Ingram DA, Flynn PJ, Rutherford CF, Rogers H. Evoked potentials during isoflurane anaesthesia. Br J Anaesth 1986; 58: 580-5.
  • 22 Schwender D, Keller I, Schlund M. Akusti-sche evozierte Potentiale mittlerer Latenz und intraoperative Aufwachreaktionen wahrend Narkoseaufrechterhaltung mit Propofol, Isofluran und Flunitrazepam/ Fentanyl. Anaesthetist 1991; 40: 214-21.
  • 23 Thornton C, Konieczko K, Jones JG, Jordan C, Dore CJ, Heneghan CPH. Effect of surgical stimulation on the auditory evoked response. Br J Anaesth 1988; 60: 372-8.
  • 24 Newton DEF, Thornton C, Creagh-Barry P, Dore CJ. Early cortical auditory evoked response in anaesthesia: comparison of the effects of N20 and isoflurane. Br J Anaesth 1989; 62: 61-5.
  • 25 Hogan K. 40 Hz steady rate evoked potentials (SSEPs) during isoflurane-N20 anesthesia. Anesthesiology 1987; 67: a402 (abstract).
  • 26 Plourde G, Picton TW. Human auditory steady-state response during general anesthesia. Anesth Analg 1990; 70: 460-8.
  • 27 Uhl RR, Squires KC, Bruce DL, Starr A. Effect of halothane anaesthesia on the human cortical visual evoked response. Anesthesiol 1980; 53: 273-7.
  • 28 Chi Oz, Field C. Effects of enflurane on VEPS in humans. Br J Anaesth 1990; 64: 163-6.
  • 29 Thomsen CE, Christensen KN, Rosenfalck A. Computerized monitoring of depth of anaesthesia with isoflurane. Br J Anaesth 1989; 63: 36-43.
  • 30 Thomsen CE, Rosenfalck A, Nørregaard-Christensen K. Assessment of anaesthetic depth by clustering analysis and autoregres-sive modelling of electroencephalograms. Comput Meth Progr Biomed 1991; 34: 125-38.
  • 31 Thomsen CE. Hierarchical Cluster Analysis and Pattern Recognition Applied to the Electroencephalogram - Development of ADAM Advanced Depth of Anaesthesia Monitor (PhD Thesis). University of Aalborg; 1992
  • 32 Bickford RG, Brimm J, Berger L, Aung M. Application of compressed spectral array in clinical EEG. In: Kellaway P, Petersen I. eds. Automation of Clinical Electroencephalography. New York: Raven Press; 1973: 55-64.
  • 33 Scurr C, Feldman WS. Scientific Foundations of Anaesthesia. (3rd ed).. London: Heinemann; 1982
  • 34 Saidman LJ. Smith, eds. Monitoring in Anaesthesia. (2nd ed).. Boston MA: Butter-worths; 1984
  • 35 Bharath A, Mendel P, Langford RM, Kitney RI. Heart rate variability in spontaneously breathing and mechanically ventilated patients. In: Computers in Cardiology 1992. IEEE Press; 1992: 571-4.
  • 36 Stockard JJ, Bickford RG, Schauble JF. Pressure dependent cerebral ischaemia during cardiopulmonary bypass. Neurol 1973; 23: 521-9.
  • 37 Pronk RAF. EEG Processing in Cardiac Surgery (PhD Thesis). Amsterdam: Free University; 1982
  • 38 Schwartz MS, Colvin MP, Prior PF. et al. The cerebral function monitor, its value in predicting the neurological outcome in patients undergoing cardiopulmonary bypass. Anaesth 1973; 28: 611-8.
  • 39 Daube JR. Recent applications of electrophysiologic monitoring during surgery. In: Ellingson RJ, Murray NMF, Halliday AM. eds The London Symposia (EEG Suppl. 39). Amsterdam: Elsevier; 1987