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Methods Inf Med 2001; 40(02): 117-121
DOI: 10.1055/s-0038-1634472
Original Article
Schattauer GmbH

Flexible Two-Stage Designs: An Overview

P. Bauer
1   Department of Medical Statistics, University of Vienna
,
W. Brannath
1   Department of Medical Statistics, University of Vienna
,
M. Posch
1   Department of Medical Statistics, University of Vienna
› Author Affiliations
Further Information

Publication History

Publication Date:
07 February 2018 (online)

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Abstract

In this overview we introduce the basic ideas behind a new flexible approach in sequential designs. The different concepts based on two-stage combination tests and conditional error functions are brought together. We sketch the construction of p-values, confidence intervals, and median unbiased estimates. Finally, recursive combination tests are introduced which extend the flexibility to the choice of the number of interim analyses.

Keywords

Adaptive Design - Midtrial Design Modification - Two-stage Combination Test - Conditional Error Function - Confidence Interval - Recursive Combination Test
 

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