CC BY-NC-ND 4.0 · Nervenheilkunde 2018; 37(01): 53-58
DOI: 10.1055/s-0038-1631173
Kopfschmerzen
Schattauer GmbH

Kopfschmerzen bei Hirntumoren

Headache in brain tumors
S. Evers
1   Klinik für Neurologie, Krankenhaus Lindenbrunn, Coppenbrügge
› Author Affiliations
Further Information

Publication History

eingegangen am: 20 September 2017

angenommen am: 04 October 2017

Publication Date:
09 February 2018 (online)

Zusammenfassung

Kopfschmerzen sind für viele Patienten Anlass, an einen Hirntumor zu denken. Dabei sind Kopfschmerzen bei Hirntumoren als Erstsymptom selten. Im Lauf einer Hirntumorerkrankung leider aber doch bis zu ca. 80% aller Patienten an Kopfschmerzen. Am häufigsten treten Kopfschmerzen bei Tumoren in der Sellaregion und bei Infiltration schmerzsensibler Strukturen wie Meningen und bestimmte Hirnnerven auf. Hirntumore, insbesondere Hypophysenadenome, können auch idiopathische Kopfschmerzen imitieren. Dagegen sind idiopathische Kopfschmerzen kein Risikofaktor für die Entstehung von Hirntumoren. Die Behandlung der Kopfschmerzen bei Hirntumoren ist unspezifisch und schließt auch Opioide und Steroide mit ein.

Summary

Headache makes many patients fear a brain tumor. However, headache is only very rarely primary symptom of a brain tumor. In the course of brain tumors, up to 80% of all patients suffer from headache. The most frequent brain tumors causing headache are tumors of the sella region and infiltration of pain sensitive structures such as the meninges and some cranial nerves. Brain tumors, in particular pituitary adenomas, can mimic idiopathic headaches. In contrast, idiopathic headaches are not a risk factor for the development of brain tumors. The treatment of headache in brain tumors is unspecific and encompasses also opioids and steroids.

 
  • Literatur

  • 1 Hopkins A. Headache: Problems in diagnosis and management. London: Saunders; 1988
  • 2 Evers S. Kopfschmerz bei Hirntumoren. In: Diener HC. (Hrsg.). Kopfschmerzen. Referenzreihe Neurologie. Stuttgart: Thieme 2003: 140-146.
  • 3 Forsyth PA, Posner JB. Intracranial neoplasms. In: Olesen J, Tfelt-Hansen P, Welch KMA. (eds.) The headaches. Philadelphia: Lippincott Williams & Wilkins; 2000: 849-859.
  • 4 Suwanwela N, Phanthumchinda K, Kaoropthum S. Headache in brain tumor: a cross-sectional study. Headache 1994; 34: 435-438.
  • 5 Iversen HK, Strange P, Sommer W, Tjalve E. Brain tumour headache related to tumour size, histology and location. Cephalalgia 1987; 07 (Suppl. 06) 394-395.
  • 6 Ludwig CL, Smith MT, Godfrey AD, Armbrustmacher VW. A clinicopathological study of 323 patients with oligodendrogliomas. Ann Neurol 1986; 19: 15-21.
  • 7 Jaeckle KA. Causes and management of headaches in cancer patients. Oncology 1993; 07: 27-31.
  • 8 Vazquez-Barquero A, Ibanez FJ, Herrera S, Izquierdo JM, Berciano J, Pascual J. Isolated headache as the presenting clinical manifestation of intracranial tumors: a prospective study. Cephalalgia 1994; 14: 270-272.
  • 9 Clementi M, Battistella PA, Rizzi L, Boni S, Tenconi R. Headache in patients with neurofibromatosis type 1. Headache 1996; 36: 10.
  • 10 Rushton JG. Rooke Brain tumor headache. Headache 1962; 02: 147-152.
  • 11 Lavyne MH, Patterson RH. Headache and brain tumor. In: Dalessio DJ. (Hrsg) Wolff ‘s headache and other head pain. New York: Oxford University Press; 1987: 343-349.
  • 12 Dunlop RJ, Campbell CW. Cytokines and advanced cancer. J Pain Symptom Manage 2000; 20: 214-232.
  • 13 Evans RW. Diagnostic testing for the evaluation of headaches. Neurol Clin 1996; 14: 1-26.
  • 14 Forsyth PA, Posner JB. Headaches in patients with brain tumors: a study of 111 patients. Neurology 1993; 43: 1678-1683.
  • 15 Pfund Z, Szapary L, Jaszberenyi O, Nagy F, Czopf J. Headache in intracranial tumors. Cephalalgia 1999; 19: 787-790.
  • 16 Schankin CJ, Ferrari U, Reinisch VM, Birnbaum T, Goldbrunner R, Straube A. Characteristics of brain tumour-associated headache. Cephalalgia 2007; 27: 904-911.
  • 17 Nelson S, Taylor LP. Headaches in brain tumor patients: primary or secondary?. Headache 2014; 54: 776-785.
  • 18 Levy MJ, Matharu MS, Meeran K, Powell M, Goadsby PJ. The clinical characteristics of headache in patients with pituitary tumours. Brain 2005; 128: 1921-1930.
  • 19 Sörös P, Evers S. Symptomatischer Clusterkopfschmerz. Klinik, Diagnostik und mögliche Pathogenese. Nervenheilkunde 2001; 20: 370-374.
  • 20 Pascual J, Iglesias F, Oterino A, Vazquez-Barquero A, Berciano J. Cough, exertional, and sexual headaches: an analysis of 72 benign and symptomatic cases. Neurology 1996; 46: 1520-1524.
  • 21 Kurth T, Buring JE, Rist PM. Headache, migraine and risk of brain tumors in women: prospective cohort study. J Headache Pain 2015; 16: 501.
  • 22 Greenberg HS, Deck MD, Vikram B, Chu FC, Posner JB. Metastasis to the base of the skull: clinical findings in 43 patients. Neurology 1981; 31: 530-537.
  • 23 Siegel S, Weber RCarneiro, Buchfelder M, Kleist B, Grzywotz A, Buslei R, Bingel U, Brabant G, Schenk T, Kreitschmann-Andermahr I. Presence of headache and headache types in patients with tumors of the sellar region-can surgery solve the problem? Results of a prospective single center study. Endocrine 2017; 56: 325-335.
  • 24 Childhood Brain Tumor Consortium (CBTC). The epidemiology of headache among children with brain tumor. J Neurooncol 1991; 10: 31-46.
  • 25 Schankin CJ, Reifferscheid AK, Krumbholz M, Linn J, Rachinger W, Langer S, Sostak P, Arzberger T, Kretzschmar H, Straube A. Headache in patients with pituitary adenoma: clinical and paraclinical findings. Cephalalgia 2012; 32: 1198-1207.
  • 26 Russo M, Villani V, Taga A, Genovese A, Terrenato I, Manzoni GC, Servadei F, Torelli P, Pace A. Headache as a presenting symptom of glioma: A cross-sectional study. Cephalalgia 2017; 57 (04) 663-664.
  • 27 Guillamo JS, Monjour A, Taillandier L, Devaux B, Varlet P, Haie-Meder C, Defer GL, Maison P, Mazeron JJ, Cornu P, Delattre JY. Brainstem gliomas in adults: prognostic factors and classification. Brain 2001; 124: 2528-2539.
  • 28 Cala LA, Mastaglia FL. Computerized axial tomography findings in a group of patients with migrainous headaches. Proc Aust Assoc Neurol 1976; 13: 35-41.
  • 29 Pepin EP. Cerebral metastasis presenting as migraine with aura. Lancet 1990; 336: 127-128.
  • 30 Schlake HP, Grotemeyer KH, Husstedt IW, Schuierer G, Brune GG. Symptomatic migraine: intracranial lesions mimicking migrainous headache – a report of three cases. Headache 1991; 31: 661-665.
  • 31 Verma A, Rosenfeld V, Forteza A, Sharma KR. Occipital lobe tumor presenting as migraine with typical aura. Headache 1996; 36: 49-52.
  • 32 De Angelis LM, Payne R. Lymphomatous meningitis presenting as atypical cluster headache. Pain 1987; 30: 211-216.
  • 33 Greve E, Mai J. Cluster headache-like headaches: a symptomatic feature? A report of three patients with intracranial pathological findings. Cephalalgia 1988; 08: 79-82.
  • 34 Hannerz J. A case of parasellar meningioma mimicking cluster headache. Cephalalgia 1989; 09: 265-269.
  • 35 Taub E, Argoff CE, Winterkorn JMS, Milhorat TH. Resolution of chronic cluster headache after resection of a tentorial meningioma: case report. Neurosurgery 1995; 37: 319-321.
  • 36 Milos P, Havelius U, Hindfelt B. Clusterlike headache in a patient with a pituitary adenoma. With a review of the literature. Headache 1996; 36: 184-188.
  • 37 Tajti J, Sas K, Szok D, Voros E, Vecsei L. Clusterlike headache as a first sign of brain metastases of lung cancer. Headache 1996; 36: 259-260.
  • 38 Porta-Etessam J, Ramos-Carrasco A, Berbel-Garcia A, Martinez-Salio A, Benito-Leon J. Clusterlike headache as first manifestation of a prolactinoma. Headache 2001; 41: 723-725.
  • 39 Edvardsson B. Cluster headache associated with a clinically non-functioning pituitary adenoma: a case report. J Med Case Rep 2014; 08: 451.
  • 40 Medina JL. Organic headaches mimicking chronic paroxysmal hemicrania. Headache 1992; 32: 73-74.
  • 41 Vijayan N. Symptomatic chronic paroxysmal hemicrania. Cephalalgia 1992; 12: 111-113.
  • 42 Massiou H, Launay JM, Levy C, El Amrani M, Emperauger B, Bousser MG. SUNCT syndrome in two patients with prolactinomas and bromocriptine-induced attacks. Neurology 2002; 58: 1698-1699.
  • 43 Kutschenko A, Liebetanz D. Meningioma causing gabapentin-responsive secondary SUNCT syndrome. J Headache Pain 2010; 11: 359-361.
  • 44 Musuka TD, Edis RH, Kermode AG. Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing caused by a pituitary adenoma. J Clin Neurosci 2013; 20: 1180-1181.