The Role of the Interaction between Fe(III) and Cell Surface in the Accumulation of 67Ga by Tumor Cells

L. J. Anghileri; P. Maleki; A. Cordova Martinezi; M. C. Crone-Escanye; J. Robert

doi:10.1055/s-0038-1629590

Nuklearmedizin - NuclearMedicine, Table of Contents

Nuklearmedizin 1991; 30(06): 290-293
DOI: 10.1055/s-0038-1629590

ÜBersichtsartikel - Review Articles

Schattauer GmbH

The Role of the Interaction between Fe(III) and Cell Surface in the Accumulation of ⁶⁷Ga by Tumor Cells

L. J. Anghileri

¹From the Biophysics Laboratory, Faculty of Medicine, University of Nancy, France

,

P. Maleki

¹From the Biophysics Laboratory, Faculty of Medicine, University of Nancy, France

,

A. Cordova Martinezi^*

,

M. C. Crone-Escanye

¹From the Biophysics Laboratory, Faculty of Medicine, University of Nancy, France

,

J. Robert

¹From the Biophysics Laboratory, Faculty of Medicine, University of Nancy, France

› Author Affiliations

Abstract

The study of the interaction between complexed iron and tumor cells in the presence of ⁶⁷Ga-citrate indicates that a phenomenon of iron-binding related to the thermodynamic constant of stability of the iron complex, and a hydrolysis (or anion penetration) of the interaction product determine the uptake of ⁶⁷Ga. The effects of various parameters such as ionic composition of the medium, nature of the iron complex, time of incubation and number of cells are discussed.

Zusammenfassung

Die Untersuchung der Wechselwirkung zwischen einem Eisenkomplex und Tumorzellen in Gegenwart von ⁶⁷Ga weist darauf hin, daß ein Phänomen der Eisenbindung, das in Beziehung zur thermodynamischen Stabilitätskonstante des Eisenkomplexes steht, und eine Hydrolyse (oder Anionenpenetration) des Wechselwirkungsprodukts die Aufnahme des ⁶⁷Ga bestimmen. Die Effekte verschiedener Parameter wie Ionenzusammensetzung des Mediums, Art des Eisenkomplexes, Dauer der Inkubation und Anzahl der Zellen warden besprochen.

Full Text

References

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