Aktuelles zu Bewährtem und neue Optionen in der Therapie

Zusammenfassung

Die in den vergangenen 12 Monaten in Deutschland zugelassenen vier Medikamente zur Behandlung der schubförmigen Form der Multiplen Sklerose (Alemtuzumab, pegyliertes Betainterferon, Dimethylfumarat, Teriflunomid) werden ausführlich vorgestellt. Zusätzlich wird ein kurzer Überblick über die neuen Erkenntnisse der bewährten MS-Therapeutika gegeben. Neben der medizinischen Nutzen-Risiko-Abwägung, die insbesondere für die drei Therapeutika der Behandlung der (hoch)aktiven Form: Alemtuzumab, Fingolimod, Natalizumab gilt, werden die individuelle Patientensituation (Schwangerschaftswunsch, Compliance von Nachkontrollen) und die Applikationsform als wichtiges Entscheidungsmerkmal der Patienten diskutiert.

Summary

Four new drugs (alemtuzumab, pegylated betainterferon, dimethylfumarate, teriflunomid) were available in the treatment of relapsingremitting multiple sclerosis within the last 12 months in Germany. These drugs were discussed in detail. Additionally there is a short overview about the new insides of the well known MS drugs. The benefit-risk ratio, that is important especially for the three treatment options (alemtuzmab, fingolimod, natalizumab) of the highly active multiple sclerosis, the individual situation of the patient (planned pregnancy, compliance of redundant safety visits), and the kind of application are presented as important reasons for the therapeutic decision of the patient.

Schlüsselwörter

Multiple Sklerose - neue Therapien - Alemtuzumab - Betainterferone - Dimethylfumarat - Fingolimod - Natalizumab - Teriflunomid

Keywords

Multiple sclerosis - new therapies - alemtuzumab - dimethylfumarate - fingolimod - natalizumab - teriflunomid

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