Subscribe to RSS
Download PDF
DOI: 10.1055/s-0038-1627323
Funktionelle Neuroanatomie der Inselrinde
Functional neuroanatomy of the insular cortexPublication History
Eingegangen am:
27 February 2008
angenommen am:
02 March 2008
Publication Date:
20 January 2018 (online)
Zusammenfassung
Morphologie und Konnektivität der Inselrinde sind trotz ihrer verdeckten Lage in der Fissura lateralis gut untersucht worden. Neuere Studien der Rezeptorarchitektur und funktionelle Messungen erweitern das Gesamtbild einer komplex gegliederten Struktur mit (peri-)allokortikalen und (pro-)isokortikalen Anteilen, die vom Limen insulae nach posterodorsal fortschreitend in Struktur und Funktion den jeweils angrenzenden Arealen am meisten verbunden sind. Hohe Konzentrationen ionotroper Glutamatrezeptor-Subtypen sind neben der ausgeprägten cholinergen Innervation vermutlich für die Neigung zur Ausbreitung von epileptiformer Aktivität mit verantwortlich.
Summary
Morphology and connectivity of insular cortex have been well investigated despite its hidden position in the lateral fissure. Recent receptorarchitectural and functional studies have extended the picture of a complex structure with (peri-) allocortical and (pro-) isocortical parts, reaching from and linking the limen insulae in the posterodorsal direction to adjacent regions with similar structural and functional characteristics. High concentrations of ionotropic glutamate receptor subtypes in addition to the dense cholinergic innervation are likely involved in the propensity to spread of epileptiform activity in this structure.
-
Literatur
- 1 Augustine JR. Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Rev 1996; 22: 229-244.
- 2 Blinkov SM, Glezer II. Das Zentralnervensystem in Zahlen und Tabellen. Jena: VEB Gustav Fischer Verlag; 1968
- 3 Clark TE. The comparative anatomy of the insula. J Comp Neurol 1896; 6: 59-100.
- 4 Kötter R, Meyer N. The limbic system: A review of its empirical foundation. Behav Brain Res 1992; 52: 105-127.
- 5 Kötter R, Wanke E. Mapping brains without coordinates. Philos Tran R Soc Lond B Biol Sci 2005; 360: 751-766.
- 6 Lewis ME, Mishkin M, Bragin E, Brown RM, Pert CB, Pert A. Opiate receptor gradients in monkey cerebral cortex: correspondence with sensory processing hierarchies. Science 1981; 211: 1166-1169.
- 7 Mesulam MM, Mufson EJ. The insula of Reil in man and monkey. In: Peters A, Jones EG. (ed.) Cerebral Cortex, Vol. 4, Chapter 5,179–225. New York: Plenum; 1985
- 8 Nieuwenhuys R, Voogd J, van Huijzen C. The Human Central Nervous System. Berlin: Springer; 1988
- 9 Nimchinsky EA, Gilissen E, Allman JM, Perl DP, Erwin JM, Hof PR. A neuronal morphologic type unique to humans and great apes. Proc Natl Acad Sci USA 1999; 96: 5268-5273.
- 10 Reil JC. Die sylvische Grube. Arch Physiol (Halle) 1809; 9: 195-208.
- 11 Rivier F, Clarke S. Cytochrome oxidase, acetylcholinesterase, and NADPH-diaphorase staining in human supratemporal and insular cortex: evidence for multiple auditory areas. Neuroimage 1997; 6: 288-304.
- 12 Türe U, Yaşargil MG, Al-Mefty O, Yaşargil DC. Arteries of the insula. J Neurosurg 2000; 92: 676-687.
- 13 Zilles K, Palomero-Gallagher N, Grefkes C, Scheperjans F, Boy C, Amunts K, Schleicher A. Architectonics of the human cerebral cortex and transmitter receptor fingerprints. Reconciling functional neuroanatomy and neurochemistry. Eur Neuropsychopharmacol 2002; 12: 587-599.
- 14 Zilles K, Palomero-Gallagher N, Schleicher A. Transmitter receptors and functional anatomy of the cerebral cortex. J Anat 2004; 205: 417-432.