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Nervenheilkunde 2008; 27(05): 425-429
DOI: 10.1055/s-0038-1627323
Original- und Übersichtsarbeiten - Original and Review Articles
Schattauer GmbH

Funktionelle Neuroanatomie der Inselrinde

Functional neuroanatomy of the insular cortex
R. Kötter
1   Donders Centre for Neuroscience, Department of Cognitive Neuroscience, Section Neurophysiology and Neuroinformatics, Radboud University Medical Centre, 6500 HB Nijmegen, Niederlande, und C. & O. Vogt Institut für Hirnforschung und Institut für Anatomie II, Heinrich-Heine-Universität, Düsseldorf
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Publication History

Eingegangen am: 27 February 2008

angenommen am: 02 March 2008

Publication Date:
20 January 2018 (online)

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Zusammenfassung

Morphologie und Konnektivität der Inselrinde sind trotz ihrer verdeckten Lage in der Fissura lateralis gut untersucht worden. Neuere Studien der Rezeptorarchitektur und funktionelle Messungen erweitern das Gesamtbild einer komplex gegliederten Struktur mit (peri-)allokortikalen und (pro-)isokortikalen Anteilen, die vom Limen insulae nach posterodorsal fortschreitend in Struktur und Funktion den jeweils angrenzenden Arealen am meisten verbunden sind. Hohe Konzentrationen ionotroper Glutamatrezeptor-Subtypen sind neben der ausgeprägten cholinergen Innervation vermutlich für die Neigung zur Ausbreitung von epileptiformer Aktivität mit verantwortlich.

Summary

Morphology and connectivity of insular cortex have been well investigated despite its hidden position in the lateral fissure. Recent receptorarchitectural and functional studies have extended the picture of a complex structure with (peri-) allocortical and (pro-) isocortical parts, reaching from and linking the limen insulae in the posterodorsal direction to adjacent regions with similar structural and functional characteristics. High concentrations of ionotropic glutamate receptor subtypes in addition to the dense cholinergic innervation are likely involved in the propensity to spread of epileptiform activity in this structure.

Schlüsselwörter

Zytoarchitektur - Verschaltung - Rezeptordichteverteilung - cholinerge Innervation - Epilepsie

Keywords

Cytoarchitecture - connectivity - receptor densities - cholinergic innervation - epilepsy
 

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