The Developing Placenta in Selecting Potential Radiopharmaceuticals for Tumour-Localizing Properties: A Simple In Vivo Pre-Screening Model^[*]

Summary

The tissue distribution of various radiopharmaceuticals was investigated in rhabdomyosarcoma-bearing and in pregnant rats during the period of rapid foetal and placental growth (days 17-19 of pregnancy). The preliminary results indicate that with the radiopharmaceuticals tested the uptake in placental tissue followed closely the data obtained with tumour tissue in rhabdomyosarcoma-bearing rats.

Zusammenfassung

Es wurde die GewebsVerteilung verschiedener Radiopharmaka bei Ratten mit Rhabdomyosarkom und bei schwangeren Ratten während der Periode des schnellen fötalen und plazentaren Wachstums (17. bis 19. Tag der Schwangerschaft) untersucht. Vorläufige Ergebnisse zeigen, daß bei den geprüften Radiopharmaka die Speicherung im Plazentagewebe jener im Tumorgewebe bei Ratten mit Rhabdomyosarkom parallel ging.

^* 3rd International Symposium on Radiopharmacology, Freiburg i.Br., September 1983.

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