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Nuklearmedizin 1984; 23(01): 19-21
DOI: 10.1055/s-0038-1624161
Originalarbeiten - Original Articles
Schattauer GmbH

The Developing Placenta in Selecting Potential Radiopharmaceuticals for Tumour-Localizing Properties: A Simple In Vivo Pre-Screening Model[*]

Die sich entwickelnde Plazenta in der Auswahl potentieller Radiopharmaka mit Eigenschaften der Tumorspeicherung: Ein einfaches In-vivo-Modell
A. Hoekstra
1   From the Radionuclide Centre, Free University, Amsterdam, The Netherlands
,
C. M. Vos
1   From the Radionuclide Centre, Free University, Amsterdam, The Netherlands
,
J. D. M. Herscheid
1   From the Radionuclide Centre, Free University, Amsterdam, The Netherlands
› Author Affiliations
Further Information

Publication History

Received: 16 September 1983

Publication Date:
10 January 2018 (online)

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Summary

The tissue distribution of various radiopharmaceuticals was investigated in rhabdomyosarcoma-bearing and in pregnant rats during the period of rapid foetal and placental growth (days 17-19 of pregnancy). The preliminary results indicate that with the radiopharmaceuticals tested the uptake in placental tissue followed closely the data obtained with tumour tissue in rhabdomyosarcoma-bearing rats.

Zusammenfassung

Es wurde die GewebsVerteilung verschiedener Radiopharmaka bei Ratten mit Rhabdomyosarkom und bei schwangeren Ratten während der Periode des schnellen fötalen und plazentaren Wachstums (17. bis 19. Tag der Schwangerschaft) untersucht. Vorläufige Ergebnisse zeigen, daß bei den geprüften Radiopharmaka die Speicherung im Plazentagewebe jener im Tumorgewebe bei Ratten mit Rhabdomyosarkom parallel ging.

* 3rd International Symposium on Radiopharmacology, Freiburg i.Br., September 1983.


 

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