Download PDF
Hamostaseologie 2008; 28(S 01): S104-S105
DOI: 10.1055/s-0037-1621631
Original article
Schattauer GmbH

Recombinant expression of wildtype and mutated γ-glutamyl carboxylase

Rekombinante Expression von Wildtyp- und mutierter γ-Glutamyl-Carboxylase
K. Siegel
1   Institut für Humangenetik, Universität Würzburg
,
S. Rost
1   Institut für Humangenetik, Universität Würzburg
,
C. R. Mueller
1   Institut für Humangenetik, Universität Würzburg
,
J. Oldenburg
2   Institut für Exp. Hämatologie und Transfusionsmedizin, Universitätsklinikum Bonn
› Author Affiliations
Further Information

Publication History

Publication Date:
04 January 2018 (online)

Also available at
    Permissions and Reprints

 

 

  • References

  • 1 Rishavy MA, Hallgren KW, Yakubenko AV. et al. Brønsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation. Biochemistry 2006; 45: 13239-13248.
    CrossrefPubMedGoogle Scholar
  • 2 Rost S, Fregin A, Koch D. et al. Compound heterozygous mutations in the γ-glutamyl carboxylase gene cause combined deficiency of all vitamin K-dependent blood coagulation factors. Br J Haematol 2004; 126: 546-549.
    CrossrefPubMedGoogle Scholar
  • 3 Tie J, Wu SM, Jin D. et al. A topological study of the human γ-glutamyl carboxylase. Blood 2000; 96: 973-978.
    PubMedGoogle Scholar