Abstract
Magnetic resonance imaging (MRI) provides an effective and noninvasive means by which
to evaluate articular cartilage within the knee. Existing techniques can be utilized
to detect and monitor longitudinal changes in cartilage status due to injury or progression
of degenerative disease. Quantitative MRI (qMRI) techniques can provide a metric by
which to evaluate the efficacy of cartilage repair techniques and offer insight into
the composition of cartilage and cartilage repair tissue. In this review, we provide
background on MR signal generation and decay, the utility of morphologic MRI assessment,
and qMRI techniques for the biochemical assessment of cartilage (dGEMRIC, T2, T2*,
T1ρ, sodium, gagCEST). Finally, the description and utility of these qMRI techniques
for the evaluation of cartilage repair are discussed.
Keywords
knee articular cartilage imaging - quantitative MRI - T1rho, T2, and T2* mapping -
cartilage morphology and biostructure