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Semin Respir Crit Care Med 2018; 39(01): 045-055
DOI: 10.1055/s-0037-1617412
Review Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Respiratory Viruses and Asthma

Peter A. B. Wark
1   Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia
2   Department of Respiratory and Sleep Medicine, John Hunter Hospital, New South Wales, Australia
,
James Michael Ramsahai
1   Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia
2   Department of Respiratory and Sleep Medicine, John Hunter Hospital, New South Wales, Australia
,
Prabuddha Pathinayake
1   Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia
2   Department of Respiratory and Sleep Medicine, John Hunter Hospital, New South Wales, Australia
,
Bilal Malik
1   Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia
,
Nathan W. Bartlett
1   Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia
3   School of Biomedical Sciences, The University of Newcastle, New South Wales, Australia
› Author Affiliations
Further Information

Publication History

Publication Date:
10 February 2018 (online)

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Abstract

Asthma remains the most prevalent chronic respiratory disorder, affecting people of all ages. The relationship between respiratory virus infection and asthma has long been recognized, though remains incompletely understood. In this article, we will address key issues around this relationship. These will include the crucial role virus infection plays in early life, as a potential risk factor for the development of asthma and lung disease. We will assess the impact that virus infection has on those with established asthma as a trigger for acute disease and how this may influence asthma throughout life. Finally, we will explore the complex interaction that occurs between the airway and the immune responses that make those with asthma so susceptible to the effects of virus infection.

Keywords

asthma - viruses - bronchiolitis - respiratory syncytial virus - rhinovirus - airway microbiota - genetic susceptibility
 

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