Download PDF
Thromb Haemost 2000; 83(05): 796-797
DOI: 10.1055/s-0037-1613918
Letters to the Editor
Schattauer GmbH

Lack of Association of the Prothrombin Gene Variant G20210A with Myocardial Infarction in Caucasian Males

Florence Coulet
1   From the Molecular Genetics Laboratory, Paris, France
,
Véronique Godard
1   From the Molecular Genetics Laboratory, Paris, France
,
Elisabeth Verdy
2   Haematology Laboratory, Tenon Hospital, Paris, France
,
Florent Soubrier
1   From the Molecular Genetics Laboratory, Paris, France
› Author Affiliations
Further Information

Publication History

Received 14 September 1999

Accepted after resubmission 15 December 1999

Publication Date:
08 December 2017 (online)

    Permissions and Reprints

 

 

  • References

  • 1 Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH. High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance). Blood 1995; 85: 1504-8.
    PubMedGoogle Scholar
  • 2 Poort SR, Rosendaal FR, Reitsma PH, Bertina RM. A common genetic variation in the 3’-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 1996; 88: 3698-703.
    PubMedGoogle Scholar
  • 3 Rosendaal FR, Siscovick DS, Schwartz SM, Psaty BM, Raghunathan TE, Vos HL. A common prothrombin variant (20210 G to A) increases the risk of myocardial infarction in young women. Blood 1997; 90: 1747-50.
    PubMedGoogle Scholar
  • 4 Ridker PM, Hennekens CH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 1995; 332: 912-7.
    CrossrefPubMedGoogle Scholar
  • 5 Emmerich J, Poirier O, Evans A, Marques-Vidal P, Arveiler D, Luc G, Aiach M, Cambien F. Myocardial infarction, Arg 506 to Gln factor V mutation, and activated protein C resistance. Lancet 1995; 345: 321.
    CrossrefPubMedGoogle Scholar
  • 6 Parra HJ, Arveiler D, Evans AE, Cambou JP, Amouyel P, Bingham AD, Schaffer P, Douste-Blazy P, Luc G. et al. A case-control study of lipoprotein particles in two populations at contrasting risk for coronary heart disease. The ECTIM Study. Arterioscler Thromb 1992; 12: 701-7.
    CrossrefPubMedGoogle Scholar
  • 7 Rosendaal FR, Doggen CJ, Zivelin A, Arruda VR, Aiach M, Siscovick DS, Hillarp A, Watzke HH, Bernardi F, Cumming AM, Preston FE, Reitsma PH. Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost 1998; 79: 706-8.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 8 Franco RF, Trip MD, ten Cate H, van den Ende A, Prins MH, Kastelein JJ, Reitsma PH. The 20210 G→A mutation in the 3’-untranslated region of the prothrombin gene and the risk for arterial thrombotic disease. Br J Haematol 1999; 104: 50-4.
    CrossrefPubMedGoogle Scholar
  • 9 Doggen CJ, Cats VM, Bertina RM, Rosendaal FR. Interaction of coagulation defects and cardiovascular risk factors: increased risk of myocardial infarction associated with factor V Leiden or prothrombin 20210A. Circulation 1998; 97: 1037-41.
    CrossrefPubMedGoogle Scholar
  • 10 Gardemann A, Arsic T, Katz N, Tillmanns H, Hehrlein FW, Haberbosch W. The factor II G20210A and factor V G1691A gene transitions and coronary heart disease. Thromb Haemost 1999; 81: 208-13.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 11 Prohaska W, Schmidt M, Mannebach H, Gleichmann U, Kleesiek K. The prevalence of the prothrombin 20210 G→A mutation is not increased in angiographically confirmed coronary artery disease. Thromb Haemost 1999; 81: 161-2.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 12 Eikelboom JW, Baker RI, Parsons R, Taylor RR, van Bockxmeer FM. No association between the 20210 G→A prothrombin gene mutation and premature coronary artery disease. Thromb Haemost 1998; 80: 878-80.
    Article in Thieme ConnectPubMedGoogle Scholar
  • 13 Ridker PM, Hennekens CH, Miletich JP. G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men. Circulation 1999; 99: 999-1004.
    CrossrefPubMedGoogle Scholar