Murine thrombosis models

Sharlene M. Day; Jennifer L. Reeve; Daniel D. Myers; William P. Fay

doi:10.1055/s-0037-1613739

Thrombosis and Haemostasis, Table of Contents

Thromb Haemost 2004; 92(03): 486-494
DOI: 10.1055/s-0037-1613739

Theme Issue Article

Schattauer GmbH

Murine thrombosis models

Sharlene M. Day

¹Departments of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

,

Jennifer L. Reeve

¹Departments of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

,

Daniel D. Myers

²Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA

,

William P. Fay

¹Departments of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA

› Author Affiliations

Abstract

Summary

Due to exciting advances in molecular biology, the laboratory mouse has become an important and frequently used model for studying thrombosis. This article reviews several experimental approaches that have been used to study arterial, venous, and microvascular thrombosis in mice. The advantages and limitations of different models are examined. Related topics of mouse anesthesia, phlebotomy, and in vitro hemostasis testing are also reviewed.

Keywords

Mouse or murine - animal models - thrombosis - haemostasis

Full Text

References

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