CC BY-ND-NC 4.0 · SynOpen 2019; 03(02): 59-66
DOI: 10.1055/s-0037-1611876
paper
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First Stereoselective Total Synthesis of Ciryneol C

Ambati Sharada
a  Centre for Natural Products & Traditional Knowledge, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India   Email: nagaiah@iict.res.in
,
Lakshmi Srinivasa Rao Kundeti
a  Centre for Natural Products & Traditional Knowledge, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India   Email: nagaiah@iict.res.in
,
Kallaganti V. S. Ramakrishna
b  Centre for NMR and SC, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India
,
Kommu Nagaiah
a  Centre for Natural Products & Traditional Knowledge, CSIR-Indian Institute of Chemical Technology, Hyderabad, 500 007, India   Email: nagaiah@iict.res.in
› Author Affiliations
A.S. thanks UGC, New Delhi, India for the award of a Fellowship. The authors thank CSIR, New Delhi, India for financial support and GAP 0623 Ministry of AYUSH.
Further Information

Publication History

Received: 27 March 2019

Accepted after revision: 06 June 2019

Publication Date:
25 June 2019 (online)

CSIR-IICT, Communication No. IICT/Pubs./2019/064

Abstract

The acetylene derivative Ciryneol C was isolated from the roots of C. japonicum. The asymmetric total synthesis of Ciryneol C was achieved in seven steps, with Horner–Wittig olefination, regioselective epoxide opening, and Cadiot–Chodkiewicz coupling reactions being the key steps.

Supporting Information

 
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