CC BY-ND-NC 4.0 · SynOpen 2018; 02(04): 0298-0305
DOI: 10.1055/s-0037-1610399
paper
Copyright with the author

Efficient One-Pot Synthesis of Triazole-Linked Morpholinone Scaffolds by CuAAC in the Presence of 18-Crown-6

A. Mayooufi
a  Laboratoire Synthèse et Isolement de Molécules BioActives (SIMBA), EA7502, Université de Tours, Faculté des Sciences et Techniques, Parc de Grandmont, 32 av. Monge, 37200 Tours, France   Email: jerome.thibonnet@univ-tours.fr
b  Laboratoire de Chimie Organique Structurale et Macromoléculaire, Département de Chimie, Faculté des Sciences de Tunis, Campus Universitaire El-Manar, Rue Béchir Salem Belkheiria, 2092 Tunis, Tunisie
,
M. Romdhani-Younes
b  Laboratoire de Chimie Organique Structurale et Macromoléculaire, Département de Chimie, Faculté des Sciences de Tunis, Campus Universitaire El-Manar, Rue Béchir Salem Belkheiria, 2092 Tunis, Tunisie
,
J. Thibonnet*
a  Laboratoire Synthèse et Isolement de Molécules BioActives (SIMBA), EA7502, Université de Tours, Faculté des Sciences et Techniques, Parc de Grandmont, 32 av. Monge, 37200 Tours, France   Email: jerome.thibonnet@univ-tours.fr
› Author Affiliations
Further Information

Publication History

Received: 08 October 2018

Accepted after revision: 02 November 2018

Publication Date:
22 November 2018 (online)

Abstract

A range of bis-heterocyclic derivatives based on novel morpholinone­ and triazole heterocycles was prepared from iodo-morpholinone­. The key step in our strategy is a one-pot procedure based upon copper-catalysed alkyne-azide cycloaddition (CuAAC) from iodo-morpholinone.

Supporting Information

 
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