CC BY-ND-NC 4.0 · SynOpen 2018; 02(03): 0251-0255
DOI: 10.1055/s-0037-1610365
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First Stereoselective Total Synthesis of Tumonoic Acid A and its Derivatives

G. Nagalatha
,
Siva Ganesh Narala
,
A. Venkat Narsaiah*
SGN and GNL are grateful to UGC-New Delhi and CSIR-New Delhi, respectively, for providing Fellowships, the Ministry of Science and Technology for providing financial support under DST-SERB-GAP-0563 and the Director CSIR-IICT for providing facilities. IICT Commun. No: IICT/pubs./2018/268.
Further Information

Publication History

Received: 05 July 2018

Accepted after revision: 21 August 2018

Publication Date:
14 September 2018 (online)

Abstract

An efficient protecting-group-free synthesis of tumonoic acid A and its derivatives has been accomplished. The synthesis started from commercially available n-octanal and employs the magnesium chloride catalysed anti-aldol reaction under the Evans protocol as the key step. Ethyl tumonoate A is a new tumonoic acid derivative with anti-inflammatory activity and inhibitory activity towards calcium oscillations in neocortical neurons.

Supporting Information

 
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