Abstract
Anilines are a vital synthetic core of pharmaceuticals, agrochemicals, natural products
and building blocks. Metal-catalyzed C–H functionalization has emerged as a powerful
tool to derivatize biologically relevant molecules. To this end, the derivation of
anilines via catalytic C–H functionalization has been the subject of important new
synthetic methodology. This review focuses on the tactics used to allow regioselective
C–H functionalization of anilines.
1 Introduction
2 ortho-Selective C–H Functionalization
2.1 Palladium
2.2 Rhodium
2.3 Ruthenium
2.4 Nickel
3 meta-Selective C–H Functionalization
4 para-Selective C–H Functionalization
5 Conclusion
Key words
C–H functionalization - homogeneous catalysis - anilines - regioselectivity - aromatic