Abstract
Background Comparing the structural changes, and local host reactions to CorMatrix (CorMatrix
Cardiovascular Inc., Roswell, Georgia, United States) and different biomaterials implanted
subcutaneously in growing pig model.
Methods Four pigs harboring implanted patches of CorMatrix, Vascutek porcine pericardium
(Vascutek; Scotland, United Kingdom), SJM bovine pericardium (St. Jude Medical, Inc.,
Minnesota, United States), and Gore-Tex (W. L. Gore & Associates GmbH, Flagstaff,
Arizona, United States) were studied for 1, 3, 6, and 12 months. The explants were
examined histologically.
Results CorMatrix showed gradual and consistent patch resorption and subsiding inflammatory
and fibrosis process. Full scaffold degradation and replacement by mild fibrosis and
subcutaneous tissue were seen by 1 year. Xenopericardial patches remained intact,
and the initially severe inflammatory and fibrotic reactions reduced gradually to
moderate fibrosis and chronic inflammation. Gore-Tex showed foreign body reaction.
Conclusions Patches were biotolerated by pigs. Xenopericardial patches elicited encapsulating
fibrosis and no remodeling. CorMatrix resorbs completely and degrades consistently
without leaving residues. Lack of encapsulating fibrosis toward CorMatrix allows tissue
ingrowth and matrix remodeling.
Keywords
CorMatrix - pericardium - experimental study
