Amer J Perinatol 2017; 34(14): 1389-1395
DOI: 10.1055/s-0037-1603655
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Oropharyngeal Administration of Colostrum Increases Salivary Secretory IgA Levels in Very Low-Birth-Weight Infants

Kristen M. Glass
Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania
,
Coleen P. Greecher
Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania
,
Kim K. Doheny
Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania
Department of Neural and Behavioral Sciences, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania
› Author Affiliations
Further Information

Publication History

09 July 2016

01 May 2017

Publication Date:
02 June 2017 (eFirst)

Abstract

Aim Oropharyngeal administration of colostrum (OAC) has been proposed to provide mother's early milk to very low-birth-weight (VLBW) infants in the first few days of life. The aim of this study was to test the hypothesis that OAC would increase salivary secretory IgA (SsIgA).

Patients and Methods Overall, 30 VLBW infants randomized to receive OAC or sterile water had salivary sampling for SsIgA on the day of life (DOL) 2, 7, and 14. The incidence of late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) was determined prospectively. Within and between-group comparisons were made by paired and independent samples t-tests.

Results Baseline characteristics were similar between groups. SsIgA was higher in OAC versus the control group (p < 0.05) on DOL 7, but not subsequently on DOL 14. There was no difference in LOS or NEC.

Conclusion OAC increased SsIgA at DOL 7. A large, multicenter trial is needed to determine if OAC decreases LOS or NEC in VLBW infants.