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Am J Perinatol 2017; 34(12): 1219-1226
DOI: 10.1055/s-0037-1602421
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Effect of Low-Dose Aspirin on the Time of Onset of Preeclampsia and Time of Delivery

C. Luke Dixon
1   Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas
,
Caroline Marrs
1   Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas
,
Maged M. Costantine
1   Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas
,
Luis D. Pacheco
1   Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas
,
George R. Saade
1   Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas
,
Giuseppe Chiossi
1   Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas
› Author Affiliations
Further Information

Publication History

23 December 2016

27 March 2017

Publication Date:
26 April 2017 (online)

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Abstract

Objective To determine whether low-dose aspirin (LDA) affects the time of onset of preeclampsia and the time of delivery in high-risk women.

Study Design Secondary analysis of a multicenter randomized controlled trial of LDA (60 mg) in high-risk women. Quantile regression was used to identify the median gestational age at preeclampsia diagnosis and median gestational age at delivery, whereas logistic regression was used to determine the likelihood of preeclampsia-indicated delivery within 7 days.

Results Total of 2,479 women were randomized and 461 developed preeclampsia. The mean gestational age at enrollment was 20 ± 4 weeks. On multivariate analysis, LDA did not affect the time of preeclampsia diagnosis (coefficient −0.4 weeks, 95% CI: −1.1 to 0.2; p = 0.2), time of delivery (coefficient 0 weeks, 95% CI: −0.3 to 0.3; p = 1), or likelihood of preeclampsia-indicated delivery within 7 days (OR = 0.8; 95% CI: 0.5–1.2; p = 0.2). In multifetal gestations, preeclampsia was diagnosed at least 1 week earlier than women with diabetes or previous preeclampsia (p < 0.05), and delivery occurred at least 2 weeks prior (p < 0.001).

Conclusion LDA prophylaxis did not significantly affect time of diagnosis of preeclampsia, time of delivery, or likelihood of preeclampsia-indicated delivery within 7 days. LDA prophylaxis did not significantly affect time of diagnosis of preeclampsia, time of delivery, or likelihood of preeclampsia-indicated delivery within 7 days.

Keywords

preeclampsia - low - dose - aspirin - prevention