Abstract
Objective To determine whether low-dose aspirin (LDA) affects the time of onset of preeclampsia
and the time of delivery in high-risk women.
Study Design Secondary analysis of a multicenter randomized controlled trial of LDA (60 mg) in
high-risk women. Quantile regression was used to identify the median gestational age
at preeclampsia diagnosis and median gestational age at delivery, whereas logistic
regression was used to determine the likelihood of preeclampsia-indicated delivery
within 7 days.
Results Total of 2,479 women were randomized and 461 developed preeclampsia. The mean gestational
age at enrollment was 20 ± 4 weeks. On multivariate analysis, LDA did not affect the
time of preeclampsia diagnosis (coefficient −0.4 weeks, 95% CI: −1.1 to 0.2; p = 0.2), time of delivery (coefficient 0 weeks, 95% CI: −0.3 to 0.3; p = 1), or likelihood of preeclampsia-indicated delivery within 7 days (OR = 0.8; 95%
CI: 0.5–1.2; p = 0.2). In multifetal gestations, preeclampsia was diagnosed at least 1 week earlier
than women with diabetes or previous preeclampsia (p < 0.05), and delivery occurred at least 2 weeks prior (p < 0.001).
Conclusion LDA prophylaxis did not significantly affect time of diagnosis of preeclampsia, time
of delivery, or likelihood of preeclampsia-indicated delivery within 7 days. LDA prophylaxis
did not significantly affect time of diagnosis of preeclampsia, time of delivery,
or likelihood of preeclampsia-indicated delivery within 7 days.
Keywords
preeclampsia - low - dose - aspirin - prevention
