Am J Perinatol 2017; 34(09): 895-904
DOI: 10.1055/s-0037-1599821
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Congenital Diaphragmatic Hernia: The Side of Diaphragmatic Defect and Associated Nondiaphragmatic Malformations

Ruža Grizelj*
1  Department of Pediatrics, University of Zagreb, University Hospital Centre Zagreb, School of Medicine, Zagreb, Croatia
,
Katarina Bojanić*
2  Division of Neonatology, Department of Obstetrics and Gynecology, University Hospital Merkur, Zagreb, Croatia
,
Jurica Vuković
1  Department of Pediatrics, University of Zagreb, University Hospital Centre Zagreb, School of Medicine, Zagreb, Croatia
,
Toby N. Weingarten
3  Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota
,
Darrell R. Schroeder
4  Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota
,
Juraj Sprung
3  Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota
› Author Affiliations
Further Information

Publication History

02 November 2016

02 February 2017

Publication Date:
16 March 2017 (online)

Abstract

Background Congenital diaphragmatic hernia (CDH) has different clinical presentations depending on whether it is right sided (R-CDH) or left sided (L-CDH). Some have suggested that L-CDH and R-CDH may represent different syndromic phenotypes. This theory would be indirectly supported if different nondiaphragmatic anomalies were associated with laterality. We assessed whether CDH laterality is associated with specific types of nondiaphragmatic anomalies.

Methods Cases of CDH were retrospectively identified from five centers, and associated congenital anomalies, prenatal diagnosis, demographics, birth characteristics, and side of the CDH were analyzed. CDH characteristics were summarized according to the absence (isolated) or presence (complex) of nondiaphragmatic malformations.

Results Among 228 neonates with CDH, 140 (61%) had isolated CDH and 88 (39%) had complex CDH. Complex CDH was significantly associated with being small for gestational age (odds ratio [95% confidence interval, CI]: 8.3 [1.9–35.7]; p = 0.005) and having L-CDH (odds ratio [95% CI]: 3.6 [1.5–8.9]; p = 0.005). The overall proportion with anomalies differed by side (42% for L-CDH, 23% for R-CDH; p = 0.02), but the rates of anomalies in specific organ systems did not differ.

Conclusion The rate of associated nondiaphragmatic anomalies by specific organ system did not differ between L-CDH and R-CDH, which suggests that they represent the same phenotypic entity.

* R.G. and K.B. contributed equally to this article.