J Pediatr Intensive Care 2018; 07(01): 007-013
DOI: 10.1055/s-0037-1599150
Original Article
Georg Thieme Verlag KG Stuttgart · New York

Hollow Fiber Oxygenator Composition Has a Significant Impact on Failure Rates in Neonates on Extracorporeal Membrane Oxygenation: A Retrospective Analysis

John M. Daniel IV
Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States
,
Philip A. Bernard
Division of Pediatric Critical Care, Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States
,
Sean C. Skinner
Division of Pediatric Surgery, Department of Surgery, University of Kentucky, Lexington, Kentucky, United States
,
Prasad Bhandary
Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States
,
Ana Ruzic
Division of Pediatric Surgery, Department of Surgery, University of Kentucky, Lexington, Kentucky, United States
,
Matthew K. Bacon
Division of Pediatric Critical Care, Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States
,
Hubert O. Ballard
Division of Neonatology, Department of Pediatrics, University of Kentucky, Lexington, Kentucky, United States
› Author Affiliations
Further Information

Publication History

07 December 2016

22 January 2017

Publication Date:
07 March 2017 (eFirst)

Abstract

In extracorporeal life support (ECLS), there are two main types of oxygenators in clinical use for neonates: polymethylpentene (PMP) hollow fiber and polypropylene (PP) hollow fiber. A retrospective study was performed on neonates (n = 44) who had undergone ECLS for noncardiac indications from 2009 to 2015. Between the two groups (PMP n = 21, PP n = 23), the PP oxygenators failed 91% of the time, whereas the PMP oxygenators failed 43% of the time (p < 0.05). Analysis suggests PMP oxygenators are less prone to failure than PP oxygenators, and they require fewer number of oxygenator changes during a neonatal ECLS.